What are the side effects of sevabertinib-Hyrnuo?

Sevabertinib (sevabertinib)-Hyrnuo is a drug used to treat HER2 mutant non-small cell lung cancer (NSCLC) . Although it has significant efficacy, it also comes with certain side effects and warnings. Patients should pay special attention to the following side effects and related precautions when using Hyrnuo for treatment.

First of all,One of the possible side effects of Hyrnuo is diarrhea, which is a relatively common adverse reaction with an incidence rate of more than 20%. In addition, rash, paronychia, stomatitis, and nausea are also common adverse reactions. For these reactions, patients need to communicate with their doctors promptly so that appropriate measures can be taken to manage them.

Hyrnuo may also cause serious side effects, including liver toxicity, interstitial lung disease (ILD) or pneumonitis, eye toxicity, increased pancreatic enzyme levels, and embryo-fetal toxicity. These side effects can have a significant impact on the patient's health and therefore need to be monitored and evaluated during treatment to ensure patient safety.

In laboratory examinations, common grade 3 or 4 abnormalities also require attention. Those with an incidence rate of more than 2% include decreased potassium, increased lipase, decreased lymphocytes, decreased sodium, increased amylase, and increased liver function indicators such as ALT and AST. These laboratory abnormalities may indicate changes in the patient's physiological status and therefore require regular examination for timely detection and treatment.

In general, sevabertinib has a wide range of side effects, involving the digestive system, skin, respiratory system and liver. In order to ensure the safety and effectiveness of treatment, patients should maintain close contact with their doctors when using Hyrnuo and promptly report any discomfort and laboratory test abnormalities. Through effective monitoring and management, the risk of side effects can be reduced to the greatest extent and the patient's health and quality of life can be ensured.

Reference materials:https://en.wikipedia.org/wiki/Sevabertinib