What are the contraindications for Biken Pronol Tablets (Bituvi) and analysis of the precautions before use?

Biktarvy tablets (Biktarvy) is an oral compound antiviral drug, mainly used to treat HIV-1 infection. The drug is composed of Bictegravir (Bictegravir), Tenofovir disoproxil fumarate (Tenofovir It consists of three ingredients: alafenamide, TAF) and emtricitabine fumarate (Emtricitabine). It achieves a combined antiviral effect by inhibiting different links of HIV virus replication. BiktarvyDue to its remarkable efficacy, good tolerability and simplified medication regimen, it is widely used in treatment-naïve and HIV infected patients with limited previous treatment experience. However, like all drugs, before using Biktarvy, you must understand its contraindications and precautions to ensure safe use.

First of all, it is an absolute contraindication for those who are allergic to drug ingredients. BiktarvyContains bicluvir, tenofovir disoproxil fumarate and emtricitabine fumarate. People with severe allergic reactions (such as rash, edema, dyspnea, etc.) to any of the ingredients should not use it. At the same time, if you have a history of allergies to excipients such as lactose or other excipients in the drug, you should also use them with caution. Once an allergic reaction occurs, the medication should be stopped immediately and first aid measures should be taken to prevent serious or even life-threatening reactions.

Secondly, patients with severely impaired renal function should avoid use. Tenofovir disoproxil fumarate is excreted by the kidneys, and patients with renal insufficiency or acute kidney injury may cause the drug to accumulate in the body, thereby increasing the risk of nephrotoxicity. BiktarvyIt is generally not recommended for patients whose estimated glomerular filtration rate (eGFR) is less than 30 mL/min/1.73㎡. In addition, people with a history of kidney stones or long-term use of other nephrotoxic drugs should use it with caution after evaluating the pros and cons under the guidance of a doctor, and regularly monitor serum creatinine, urine protein and renal function indicators.

Third, it should be used with caution or disabled in patients with severe liver function abnormalities. BiktarvyBicluvir is mainly metabolized in the liver. Severe liver insufficiency (Child-Pugh C grade) may lead to drug accumulation and cause hepatotoxicity. Patients with active hepatitis or cirrhosis should use it under the guidance of a professional doctor, and regularly monitor liver function indicators (ALT, AST before and during treatment, total bilirubin, etc.). At the same time, patients with a history of severe drug-induced liver injury need to weigh the risks and benefits of use.

In addition, interactions with other medications are also important to note before use. Bicluvir in Bicronol tablets is an integrase inhibitor. If combined with certain drugs (such as potent CYP3A4 inducers: rifampicin, phenobarbital, carbamazepine, etc.), it can It can lead to a decrease in blood concentration and reduce efficacy; taking it with certain antacids or antacids containing magnesium, aluminum, and calcium will affect the absorption of TAF and emtricitabine, thereby reducing the antiviral effect. Therefore, patients must fully inform their doctors of all prescription drugs, over-the-counter drugs and health care products they are using before taking medication, and adjust the medication interval or change medications according to the doctor's instructions.

Pregnant and lactating women are also people of special concern. BiktarvyNo obvious teratogenicity has been shown in animal experiments, but human data are limited, so it should be used with caution after weighing the pros and cons during pregnancy. Use during lactation may be passed to the infant through breast milk, so breastfeeding is generally not recommended to avoid exposing the infant to antiviral drugs.

Before use, patients should also pay attention to their ownHIV virological status and comorbidities. First-time users should undergo HIV baseline viral load and drug resistance gene testing to ensure the effectiveness of drug selection. Co-infections (such as hepatitis B, hepatitis C) or long-term cardiovascular disease, osteoporosis, etc. also need to be evaluated under the guidance of a doctor for potential risks.

In general, Biktarvy tablets (Biktarvy) are a highly effective solution for modern HIV treatment. Its contraindications mainly include patients who are allergic to drug ingredients, have severe renal or liver dysfunction, and should be used with caution during pregnancy or lactation. Before use, liver and kidney function, concomitant medications, virological indicators and past medical history should be comprehensively assessed, and medication and monitoring should be strictly followed according to the doctor's instructions. These measures can maximize patient medication safety and ensure the effectiveness and tolerability of antiviral treatment.

Reference materials:https://www.drugs.com/