What are the main ingredients of 0.01% atropine sulfate eye drops (EIKANCE)

The core active ingredient of 0.01% Atropine Sulfate Eye Drops (EIKANCE) is atropine sulfate (Atropine Sulfate Monohydrate), which is an anticholinergic drug. It reduces regulatory stimulation by blocking M receptors in the eye, and has an inhibitory effect on the elongation of the axial length of the eye, thus helping to slow down the further progression of myopia. This mechanism determines that it can become one of the important drug categories for the current international management of myopia in children.

In EIKANCE, atropine sulfate exists in a low concentration form of 0.01%, which is currently internationally recognized as a safe myopia control concentration suitable for long-term use. The advantage of low concentration is that it can retain the effect of inhibiting axial growth while reducing side effects such as pupil dilation, photophobia, and blurred reading. Therefore, it has become a popular concentration for myopia management in most children. Pharmaceutical preparations are in the form of water-soluble salts, making their stability and solubility more suitable for long-term storage and daily use.

Except for the active ingredients,EIKANCE is formulated without preservatives and comes in single-use, individually packaged, low-dose eye drop bottles. The advantage of being preservative-free is that long-term use will not cause chronic irritation of the cornea or conjunctiva, and it is more in line with the characteristics of children's medication. Each 0.3mL vial is designed to avoid contamination caused by multiple openings and improve the safety of eye drops. The full box is usually 30 for easy monthly use.

Atropine itself is an early common ophthalmic drug, but its use in low-concentration fields for myopia management is an innovative use that has been widely accepted by the international medical community in recent years. Because low-concentration atropine can affect axial growth through neuromodulation pathways, more and more foreign myopia management guidelines include it in children's control programs.

Overall,Although the "main ingredient" of EIKANCE is only atropine sulfate, its value does not come only from the ingredient itself, but from concentration selection, preservative-free design, single-dose packaging and systematic application for long-term intervention in children.

Reference materials:https://www.eikance.com.au/