Comprehensive analysis of the pharmacological effects and mechanisms of DaliRasheng (Keweike)

Daridorexant is a new dual antagonist that mainly acts on the orexin receptor (orexin receptor) in the central nervous system and shows unique pharmacological properties in the treatment of insomnia. Its mechanism of action is mainly through selective antagonism of Orexin 1 receptor (OX1R) and Orexin 2Receptors (OX2R) inhibit excessive excitability of neurons, thereby helping to regulate the sleep-wake cycle. Compared with traditional benzodiazepine hypnotics, Dalitrazolin does not directly act on GABA receptors, so it has better safety in terms of sedative side effects and cognitive function suppression.

Specifically, Dali Rexen inhibits the activity of Orexin neurons, thereby inhibiting the brain's arousal pathways without affecting the natural sleep structure. OrexinNeurones play a key role in maintaining wakefulness and wakefulness, and their overactivity can lead to difficulty falling asleep or frequent awakenings during the night. Through dual antagonistic effects, DaliRasen can not only shorten the time it takes to fall asleep, but also reduce the number of nighttime awakenings, thereby improving sleep efficiency and overall sleep quality.

In addition, the pharmacokinetics of Dalirasin are rapid onset of action and moderate half-life. It is rapidly absorbed after oral administration, and the blood concentration reaches a peak within a short period of time, which is beneficial to falling asleep. At the same time, its half-life is moderate, which can ensure continuous sleep at night and avoid drowsiness or residual sedative effects the next day. This balance makes Dalilaysan both safe and effective in treating insomnia patients, especially for middle-aged and elderly people or people who have tolerance problems with long-term use of hypnotics.

Finally, the pharmacological effects of DaliRasen are not limited to sleep improvement, but also have a positive impact on daytime wakefulness and maintenance of cognitive function. Studies have shown that patients’ mental status improved significantly after they woke up after taking the medicine, daytime sleepiness was reduced, and their quality of life was improved. Overall, DaliRasen achieves precise regulation of arousal pathways through selective dual antagonism of Orexin receptors, providing a safe and efficient new treatment option for insomnia patients.

Reference materials:https://www.drugs.com/