The clinical effect and precautions of DaliRasheng (Keweike) in shortening the time to fall asleep

Daridorexant (trade name: Keweike) is a new type of oral dual orexin receptor antagonist (dual orexin receptor antagonist, DORA), mainly used to treat primary insomnia. Its mechanism of action is by selectively antagonizing Orexin 1 and Orexin 2 receptors, reducing brain wake-up signals, helping patients fall asleep faster, and improving the ability to maintain sleep at night. The development of DaliRazen provides a different treatment strategy for the treatment of insomnia than traditional benzodiazepines, reducing the risk of dependence and impact on cognitive function.

In clinical studies, DaliRasen has shown the efficacy of significantly shortening the time it takes to fall asleep. Multiple randomized controlled trials have shown that the average time it takes for patients to fall asleep is approximately 15 to 20 minutes shorter than the placebo group, and the number of nighttime awakenings is significantly reduced. Results of long-term treatment (e.g. 12 weeks) show improvements in sleep efficiency and overall sleep quality. In addition, DaliRasen also shows certain advantages in improving sleep structure, such as prolonging the proportion of deep sleep stages and helping patients obtain more restorative sleep.

Despite its remarkable efficacy, you still need to pay attention to safety precautions when using DaliRasen. Patients should evaluate their liver and kidney function before taking the drug and avoid co-administration with strong CYP3A4 inhibitors or inducers to prevent abnormal drug concentrations. Medications are generally recommended to be taken orally at bedtime and to ensure at least 7 hours of sleep to reduce the risk of next-day drowsiness and difficulty concentrating. Elderly patients and patients with respiratory diseases (such as obstructive sleep apnea or chronic obstructive pulmonary disease) should use it with caution and adjust the dose under the guidance of a doctor if necessary.

In addition, DaliRazen may cause mild adverse reactions such as headache, drowsiness, somnolence, or nausea. Patients should avoid driving or operating machinery immediately after taking the medication to prevent accidents. If severe side effects or persistent discomfort occur, you should contact your doctor promptly to adjust the treatment plan. Taken together, DaliRasen has a clear effect in shortening the time it takes to fall asleep and improving sleep quality, but it needs to be used regularly under the guidance of a doctor and combined with lifestyle intervention (such as regular work and rest, reducing caffeine intake) to obtain the best efficacy and safety.

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