Explanation on whether talquetamab-tgvs is a targeted drug

Talquetamab is classified as a bispecific antibody drug. It is neither a small molecule targeted drug in the traditional sense nor a classic immune drug with a single target. Instead, it is an immunotherapy category between the two with a highly precise mechanism of action. Its core feature is that it recognizes two targets at the same time: one exists on the surface of multiple myeloma cells, and the other is located on the surface ofT cells, thereby achieving a "bridging" effect and allowing the patient's own immune cells to attack tumor cells more accurately and more concentratedly.

Although it is not a traditional small molecule targeted therapy drug, it has the characteristics of "target specificity", that is, it completes tumor localization by recognizing specific proteins on the surface of myeloma cells. Unlike traditional targeted drugs that rely on inhibition of enzyme activity or blocking of signaling pathways, Taquitumumab mainly activates the killing mechanism of immune cells and is an immune system-mediated treatment. Therefore, it is usually classified as an "immunotherapy drug" and more specifically a "T cell redirecting bispecific antibody."

The advantages of this type of drug are precise action and strong immune dependence. It does not require high-dose chemotherapy to kill tumors. Therefore, it is suitable for patients who have undergone multiple lines of treatment, especially when they relapse or have insufficient tolerance to previous regimens. Overseas guidelines describe it as an innovative "cell-to-cell connection" mechanism drug, with immune activation as its core and having precise positioning characteristics similar to targeted drugs. Therefore, in medical classification, it is usually interpreted as "immune targeted fusion therapy".

In summary, Tacistumumab is not a targeted drug in the traditional sense, but it has targeting characteristics in its mechanism and belongs to the category of immunotherapy. It is a new dual-antibody drug with both the advantages of precision and immunity.

Reference materials:https://www.talveyhcp.com/