List of contraindications for which drugs Sotolaxib (AMG 510) should not be taken at the same time

Sotoracib is mainly metabolized by CYP3A4 in the body, so potent CYP3A4 inducers (such as rifampicin, carbamazepine, phenytoin, St. John's wort, etc.) will significantly accelerate the drug metabolism, leading to a decrease in blood drug concentration, thus weakening the anti-tumor effect. Concomitant use with these drugs is not clinically recommended. If related drugs must be used, doctors should adjust the dose or choose other alternatives that do not affect CYP3A4 metabolism to avoid reduced efficacy.

Contrary to inducers, potent CYP3A4 inhibitors (such as ketoconazole, itraconazole, clarithromycin, ritonavir, etc.) will inhibit the metabolism of sotoraxib, causing it to accumulate in the body and increase the risk of adverse reactions, such as diarrhea, abnormal liver function or fatigue. If clinical use is necessary, the patient's tolerance should be closely monitored, and if necessary, reduction of the dose of sotoraxib or replacement of the corresponding inhibitor drug should be considered.

Sotoracib is sensitive to intragastric pH values. When taken simultaneously with proton pump inhibitors (such as omeprazole, esomeprazole), H₂ receptor antagonists (such as ranitidine), or antacids, it will lead to a decrease in gastric acid and drug solubility, thereby reducing the absorption and blood concentration of sotoraxib. It is recommended to avoid concurrent use of these drugs. If it is necessary to use antacids, they should be staggered by at least 4 hours with sotoraxib to reduce the impact.

In addition to the above three categories, sotoracib may also interact with P-gp substrates, BCRP substrates and other drugs, such as digoxin, dabigatran, statins, etc., which may change the in vivo exposure levels of these drugs. In addition, it is not recommended to use it concurrently with drugs with clear hepatotoxicity or nephrotoxicity to avoid increasing organ burden. Patients should proactively inform their doctors about all prescription drugs, over-the-counter drugs and health care products they are using before taking medication, and professionals will assess potential drug interaction risks and formulate a safe medication plan.

Reference materials:https://www.drugs.com/

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