Analysis of the efficacy and application of DaliRasheng (Keweike) in different types of insomnia

Daridorexant (Daridorexant) is a new type of dual orexin receptor antagonist (DORA), developed by Idorsia Pharmaceutical Company. It inhibits the overactivity of the arousal system by selectively blocking the orexin 1 type and 2 type receptors in the brain, thus promoting natural falling asleep and maintaining sleep. Unlike traditional benzodiazepines or Z drugs, Dalitrazolin does not directly inhibit the central nervous system, but regulates the sleep-wake balance. Therefore, the risk of addiction is low and the next day drowsiness is relatively mild. It is an innovative sleep-aid drug that has attracted international attention in recent years.

For insomnia patients whose main symptom is difficulty falling asleep, Dali Laxang can effectively shorten the sleep latency period and help patients fall asleep faster. Clinical studies have shown that the drug's effect gradually begins to take effect after 30 minutes of taking DaliRazen. Without disturbing the natural sleep structure, the patient's time to fall asleep is significantly shortened, and the number of nighttime awakenings is reduced. Compared with conventional sedative-hypnotics, it does not cause forced "sedation" and is therefore more suitable for patients who need to remain awake the next day.

For patients who wake up frequently at night or have difficulty maintaining sleep, DaliRasen also has good efficacy. Studies have found that the drug can continuously suppress excessive arousal signals throughout the night, extend total sleep time, increase the proportion of deep sleep, and improve sleep quality in the second half of the night. Especially among the elderly, prone to waking up at night is a common problem. Due to its mild pharmacokinetics, DaliRazo is less likely to cause residual effects the next day, making it suitable for long-term management of these patients.

DaliRasen is suitable for patients with difficulty falling asleep, maintenance insomnia or mixed insomnia, especially for those with long-term insomnia or intolerance to traditional sedatives. It is highly safe and will not cause dependence or obvious rebound after drug withdrawal. It is also suitable for use by the elderly or patients with chronic diseases. For insomnia patients who need to improve daytime wakefulness and quality of life, DaliRasen provides a treatment method that is closer to the physiological regulation mechanism and is an important innovative drug in the field of insomnia treatment.

Reference link:https://www.drugs.com