What are the side effects of Lapatinib?

Like many small molecule tyrosine kinase inhibitors, lapatinib (Lapatinib) is considered well tolerated. The most common side effects reported were diarrhea, fatigue, nausea, and rash. Of note, lapatinib-related rash was associated with improved efficacy. In clinical studies, elevated liver enzymes have been reported. QT prolongation has been observed with lapatinib, but no cases of torsade de pointes have been reported. Caution is advised in patients with hypokalemia, hypomagnesemia, congenital long QT syndrome, or concomitant use of drugs known to cause QT prolongation. Reversible decreases in left ventricular function are common with concomitant use of capecitabine.