Will Vemurafenib still be effective if used again after drug resistance?

Melanoma showed rapid response after initiating a continuous dosing regimen of Vemurafenib. This response continued with intermittent dosing, and the leg lesions continued to shrink until they completely disappeared. However, after stopping treatment, complete remission lasted for more than 2 years. Although the patient is in complete clinical remission, this does not mean that the melanoma has been completely eliminated. Resistance to vemurafenib usually appears within 6-8 months. The case study describes a patient who remained well with sustained clinical complete response after discontinuing intermittent treatment with vemurafenib for more than 24 months. However, everyone’s physique is different and their resistance to drugs is also different. If drug resistance occurs after using the drug, please inform the doctor in time and do not adjust the drug dosage yourself.