Will taking Neratinib cause diarrhea all the time?

Severe diarrhea and sequelae, such as dehydration, hypotension, and renal failure, occurred during treatment with Neratinib. In clinical trials, most patients (93%) developed diarrhea during the first month of treatment, with the median time to first onset of grade ≥3 diarrhea being 8 days, and the median cumulative duration of grade ≥3 diarrhea being 5 days. Antidiarrheal prophylaxis has been shown to reduce the incidence and severity of diarrhea. Instruct patients to use loperamide for antidiarrheal prophylaxis while taking the first dose of neratinib and to continue using it for the first 56 days of treatment; after day 56, titrate the dose to achieve 1-2 bowel movements per day, and not to exceed 16 mg of loperamide per day.