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How Neratinib Maleate Tablets Work
Neratinib (Neratinib)Immediate-release oral film-coated tablets contain40 mg of neratinib, equivalent to 48.31 mg of neratinib maleate. Neratinib is an intracellular kinase inhibitor that irreversibly binds to epidermal growth factor receptor (EGFR),HER2 and HER4. In vitro, neratinib reduced EGFR and HER2 autophosphorylation, downstream MAPK and AKT signaling pathways, and showed antitumor activity in cancer cell lines expressing EGFR and/or HER2. The human metabolites M3, M6, M7 and M11 of neratinib inhibit the activities of EGFR, HER2 and HER4 in vitro. In vivo, oral neratinib inhibited tumor growth in a mouse xenograft model with tumor cell lines expressing HER2 and EGFR.
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