Can everolimus be combined with sirolimus?

Everolimus and sirolimus (sirolimus) are both commonly used anti-cancer drugs. They are often used in the treatment of malignant tumors such as lung cancer, liver cancer, kidney cancer, and pancreatic cancer. Their mechanisms of action are similar. They can inhibit cell proliferation, promote cell apoptosis, and achieve the effect of treating tumors, but Everolimus and The scope of application of sirolimus is also different. Everolimus is mainly used for lung cancer, pancreatic cancer, liver cancer, kidney cancer, etc. Sirolimus is mainly used to prevent organ rejection (TR) in patients over 13 years old who have received kidney transplants. Everolimus can be used alone or in combination with other chemotherapy drugs, but sirolimus is usually used in combination with immunotherapy drugs.