Can Sorafenib cause hepatic ascites?

Sorafenib (Sorafenib) is a tablet that is effective in the treatment of inoperable or distantly metastatic hepatocellular carcinoma and advanced renal cell carcinoma. Ascites is a symptom of liver disease, and it is easy to develop ascites in the late stages of liver cancer. Sorafenib is effective in treating ascites. Patients with advanced liver cancer are most likely to develop ascites. This is mainly due to chronic liver function impairment, reduced albumin synthesis, decreased plasma colloid osmotic pressure or portal hypertension, which causes an imbalance of extracellular and intracellular water metabolism, and intracellular water is lost to the outside of the cells to form ascites. Ascites from liver cancer will not only increase the patient's pain, but also threaten the patient's life. Sorafenib is effective in treating this ascites and can help patients prolong their survival.