Can men take tenofovir disoproxil fumarate (Viread) to prepare for pregnancy?

In clinical animal experimental studies of tenofovir disoproxil fumarate (Viread), the dosage was 10 times that of humans. Tenofovir disoproxil fumarate will not affect fertility, early stage It has no reproductive toxicity during embryonic development. Tenofovir is a prodrug of tenofovir disoproxil. After taking it, tenofovir is metabolized under the action of esterase. It is a nucleoside analogue that terminates DNA replication by introducing viral DNA chains and inhibits the replication of hepatitis B virus or human immunodeficiency virus. Tenofovir disoproxil fumaratehas a slight effect on humanDNA polymerase, only mildly inhibits part of DNA polymerase, and has little impact on the reproductive system. Since there are no clinical reports of reproductive toxicity, tenofovir disoproxil fumarate does not affect male pregnancy preparation.