Can people with renal insufficiency take Gefapixant Citrate?

The metabolism of Gefapixant Citrate in the body is mainly excreted through the kidneys. The status of renal function directly affects the risk of drug accumulation. Therefore, patients with renal insufficiency must strictly follow the doctor's instructions to adjust the dose when taking the drug, and should not take it blindly. For patients with mild to moderate renal impairment, the glomerular filtration rate is between 30-89 mL/min, and there is no need to adjust the dosage. They can still take 45 mg twice a day as usual, and their renal function can be monitored regularly during medication. For patients with severe renal impairment, the glomerular filtration rate is between 15-29 mL/min, and the dosage needs to be reduced to 45 mg once a day to reduce the accumulation of the drug in the body. For patients with end-stage renal disease, especially those who require dialysis treatment, there is currently no clear safety data on medication and its use is not recommended.