How effective is Gefapixant Citrate in treating chronic cough?

Gemfapixin is a new type of highly selective P2X3 receptor antagonist. It is also a specialized drug for the targeted treatment of refractory chronic cough in adults. It is especially suitable for patients whose cough lasts for more than 8 weeks and whose conventional cough medicines and etiology treatments are ineffective. It also has a clear effect on chronic cough of unknown cause. Its core function is to block the P2X3 receptors on the respiratory mucosa, inhibit the abnormal excitement of the vagus nerve, block the cough reflex arc from the root, and reduce the frequency and severity of cough attacks. Clinical data shows that after taking the drug, the number of coughs in patients within 24 hours can be significantly reduced, and nighttime coughs can also be improved, greatly improving the quality of life. However, this drug is only a symptomatic treatment and cannot solve the underlying cause of the cough.