What are the side effects of druxolitinib? Is it safe for long-term use?

Drusolitinib, as aJAK inhibitor, may cause some immune-related side effects.常见不良反应包括头痛、恶心、轻度肝功能异常、血脂升高、上呼吸道感染等，多为轻中度，一般不影响用药继续。个别患者可能出现更严重的感染风险、血液学异常（如白细胞减少）、带状疱疹或肝酶升高等情况，需定期监测肝肾功能与血常规。 The safety of long-term use is under continuous observation. Current data shows that the overall tolerability is good, but it is not recommended to use it for a long time without the guidance of a doctor. Especially patients with autoimmune diseases or those using other immunosuppressants should carefully assess the risks of use.