雷帕鸣(西罗莫司片)怎么服用

Marketed by Pfizer under the trade name Rapamune, it was initially marketed as a low-toxicity antifungal drug for use in kidney transplant patients to prevent organ rejection. Used in combination with cyclosporine and corticosteroids. Rapamin (sirolimus) was discovered in 1977 to have immunosuppressive effects (inhibiting mTOR). In September 1999, the US FDA approved rapamin (sirolimus) to prevent organ transplant rejection. On May 28, 2015, rapamin (sirolimus) was approved to treat a rare lung disease, lymphangioleiomyomatosis (LAM).

How to take Rapamin (sirolimus tablets)?

Rapamin (sirolimus tablets, sirolimus) is taken orally once daily. The loading dose of rapamin should be taken for the first time, which is 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. It is recommended that rapamycin (sirolimus tablets, sirolimus) should be taken 4 hours after taking cyclosporine oral solution (modified version) and/or cyclosporine capsules (modified version) [cyclosporine microemulsion (modified version)].

Although in clinical trials, the loading dose of 15 mg and the maintenance dose of 5 mg/day of rapamin (sirolimus tablets) were safe and effective, the therapeutic benefits of doses above 2 mg are not yet clear for kidney transplant patients. The overall safety profile of patients taking 2 mg of rapamin (sirolimus tablets) daily is better than that of patients taking 5 mg of rapamin (sirolimus tablets) daily.

The therapeutic effect of rapamin (sirolimus tablets, sirolimus) is significant. Taking rapamin and sirolimus tablets for treatment will also produce certain side effects or adverse reactions, including: peripheral edema/hypertension/edema/chest pain/deep vein thrombosis/pulmonary embolism/headache/pain/dizziness/acne vulgaris/hypertriglyceridemia/diabetes/ovarian cyst/constipation/diarrhea/stomatitis, etc.

  The above is the introduction about it, I hope it can help everyone. If patients have other questions about the drug (such as drug price, purchasing channels, etc.), they can consult the medical companion travel service.

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