苯丁酸钠的不良反应是什么？用苯丁酸钠治疗时要注意什么

Sodium phenylbutyrate is primarily used to treat urea cycle disorders. Research has found that the drug is a histone deacetylase inhibitor with high efficiency and low toxicity, and can inhibit the growth of a variety of tumor cells. Studies have confirmed that sodium phenylbutyrate can induce differentiation and apoptosis of a variety of tumor cells. What are the adverse effects of that? What should you pay attention to when treating with sodium phenylbutyrate?

Adverse reactions of sodium phenylbutyrate

Adverse reactions of sodium phenylbutyrate include: ankle and peripheral edema, blood pressure changes, headache, depression, hypoalbuminemia, metabolic acidosis, alkalosis, hyperchloremia, hyperuricemia, hypokalemia, hypophosphatemia, hyperphosphatemia, hypernatremia, irregular menstrual cycles in women, renal tubular acidosis, elevated alkaline phosphatase levels, lack of appetite, nausea, vomiting, peptic ulcer, rectal bleeding, constipation, pancreatitis, thrombocytopenia, etc. If patients experience serious side effects during sodium phenylbutyrate treatment, they should go to the hospital promptly and have a professional doctor adjust the medication plan. After patients have adverse reactions, they should not use other medications without authorization, as they may cause other side effects and affect their condition.

When using sodium phenylbutyrate (sodium phenylbutyrate), attention should be paid to drug interactions. Combination of this drug with haloperidol, valproate, and corticosteroids may cause hyperammonemia, so caution should be used when combined. Sodium phenylbutyrate combined with probenecid can affect the renal excretion of phenylbutyrate metabolites, so caution should be used when combined.

Before receiving sodium phenylbutyrate (sodium phenylbutyrate) treatment, patients should inform their doctor about the drugs they are taking, and the doctor will determine whether they can be taken simultaneously with sodium phenylbutyrate (sodium phenylbutyrate). If they cannot be taken together, the medication regimen should be adjusted according to the doctor's advice.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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