今天康护乐小编带大家认识苯丁酸钠这个药物

Urea cycle disorders (UCDs) are a group of rare genetic metabolic diseases. Currently, UCDs are subdivided into 8 types of diseases based on defects in 6 enzymes and 2 transporters related to the urea cycle. Each disease of UCDs can produce mental abnormalities, with large clinical heterogeneity. It can occur from newborns to old age, making early identification difficult. Before the diagnosis is clear, they are often diagnosed with neurodevelopmental disorders such as autism, mental retardation, mental disorders, and cerebral palsy. It is a differentiation-inducing agent that can induce differentiation, apoptosis and kill a variety of tumors. It can inhibit the growth of tumor cells by inhibiting histone deacetylase and regulate the transcription levels of a variety of specific genes. It is currently a very good drug for the treatment of urea cycle disorders.

The peak time after oral administration of sodium phenylbutyrate tablets and powder is 1.35 h and 1 h respectively, and the peak time after intravenous injection is 30~60 min. Most drugs can be excreted in the urine in the form of phenylacetylglutamine within 24 hours, with a small amount excreted in the form of unchanged form and phenylacetate. The overall clearance rate is 18 mg/kg·h). Sodium phenylbutyrate tablets and powder have been approved in the European Union and the United States.

: ≥20kg (tablet or suspension): 9.9-13 g/㎡ orally divided by Q4-8 hours orally; not exceeding 20 g/day, <20 kg (suspension): 450-600 mg/kg/day divided by Q4-6 hours orally (solution only). Common side effects of this drug are hypoalbuminemia, leukopenia, metabolic acidosis, hypokalemia, amenorrhea, dysmenorrhea, strong body odor, anemia, anorexia, hyperuricemia, hypophosphatemia, hypernatremia, thrombocytopenia, etc.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.