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Sparsentan is a novel dual endothelin-angiotensin receptor antagonist primarily used to treat certain kidney diseases. This article will introduce in detail the mechanism of action of the drug, market price information and key precautions when using it to help patients fully understand this innovative therapy.

What is Sparsentan?

It is an innovative targeted therapy drug with a unique mechanism of action and treatment characteristics.

Mechanism of drug action

Sparsentan exerts its therapeutic effect by simultaneously blocking endothelin A receptors and angiotensin II type 1 receptors. This dual inhibition can effectively reduce proteinuria, protect renal function, and delay disease progression.

Main indications

The drug is approved for the treatment of proteinuria in adult patients with primary IgA nephropathy. Clinical studies have shown that it can significantly reduce urinary protein excretion and has positive significance in delaying the deterioration of renal function.

Dosage forms and specifications

The common dosage forms of sparsentane are film-coated tablets, with specifications including 200mg and 400mg. Standard treatment regimens usually start at 200 mg and are adjusted to a maintenance dose of 400 mg based on patient response.

Understanding the basic characteristics of drugs is the prerequisite for rational use. The next thing to pay attention to is the cost of treatment.

How much does Sparsentan cost?

The price of Sparsentan varies significantly depending on the place of origin and specifications, and patients can choose according to the actual situation.

Original drug price

The original drug produced by Travere Therapeutic in the United States is 400mg*30 tablets, with a reference price of approximately US$15,277 per box. This price reflects the research and development costs and patent protection of innovative drugs.

Generic drug selection

The generic drug produced by Lucius in Laos is 400mg*30 tablets, with a reference price of approximately US$1,073. Generic drugs have obvious price advantages, providing patients with more treatment options.

Factors affecting price

Drug prices are affected by many factors such as place of production, supply chain, and local medical insurance policies. Some countries may offer patient assistance programs to help alleviate the financial burden.

While considering the cost of treatment, it is also important to understand the precautions for medication.

Precautions for Sparsentan

The rational use of Sparsentan requires special attention to the following key matters to maximize the efficacy and reduce risks.

Liver function monitoring

Liver function indicators need to be checked regularly during medication. If symptoms such as nausea, fatigue, and jaundice occur, seek medical attention immediately. Medication should be suspended when transaminases increase by more than 3 times the upper limit of the normal value.

Pregnancy risk control

This drug has a clear risk of teratogenesis, and women of childbearing age must confirm that they are not pregnant before taking the drug. Reliable contraceptive measures must be taken during treatment, and pregnancy tests must be performed monthly.

Blood pressure management

May cause hypotensive reactions, especially when used in combination with diuretics or other antihypertensive drugs. Blood pressure changes should be monitored in the early stages of medication, and the dosage of other antihypertensive drugs should be adjusted if necessary.

Elderly patients and those with renal insufficiency need to adjust the dose. Avoid sudden changes in body position during medication to prevent orthostatic hypotension.