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Sparsentan is a new drug used to treat specific kidney diseases. The cost of treatment varies significantly depending on the source and strength of the drug. This article will give a detailed introduction from three aspects: dosage of treatment, price comparison, and medication precautions for special groups, to help patients fully understand the cost of using the drug and related medication specifications.

How many boxes of sparsentan are needed in one course of treatment

Understanding the dosage of standard treatment courses is of great significance to patients in formulating treatment plans and budgets.

Standard treatment plan

According to clinical trial data, the standard treatment cycle of spasentan is usually 12 weeks, and patients need to take a daily dose of 400mg, which means that each course of treatment needs to be continued for 84 days.

Drug packaging specifications

There are two common packaging specifications on the market: original drugs are 400mg*30 tablets/box, and generic drugs are also 400mg*30 tablets/box.

Number of boxes required for treatment course

Based on the daily dose of 400mg, one box of medicines can meet the medication requirements for 30 days, and a 12-week (84-day) treatment course requires about 3 boxes of medicines.

The actual dosage may be adjusted due to individual differences and doctor's advice. Patients should strictly follow the doctor's advice.

How much does a course of Sparsentan cost?

Drug price is an important consideration when patients choose a treatment plan. The prices of Sparsentan from different sources vary greatly.

Original drug price

The original drug produced by Travere Therapeutic in the United States is 400mg*30 tablets, with a reference price of approximately US$15,277 per box, and a 12-week course of treatment costs approximately US$45,831.

Price of generic drugs

The specification of generic drugs produced by Lucius in Laos is 400mg*30 tablets, the reference price is about US$1,073 per box, and the cost of a 12-week course of treatment is about US$3,219.

Price influencing factors

The main factors leading to price differences include R&D cost allocation, production process requirements, regional pricing strategies, and supply chain costs.

Patients can choose appropriate drug sources based on their own financial status and drug accessibility, while paying attention to the medical insurance reimbursement policy.

Sparsentan medication for special groups

Special groups need to pay special attention to related contraindications and medication adjustments when using sparsentan.

Pregnant women

Pregnant women are absolutely prohibited from using it. Animal experiments have shown teratogenicity (fetal craniofacial malformations at a dose of 80 mg/kg). Pregnancy testing is required before use, and reliable contraceptive measures must be taken during treatment.

Lactating women

There is currently no reliable human clinical data. It is recommended to stop breastfeeding during treatment and continue to suspend breastfeeding for 1 week after stopping the drug.

Children and the elderly

The safety and effectiveness of patients under 16 years old have not been established. The efficacy and safety of patients ≥65 years old are not significantly different from those of younger people.

Special groups must conduct a comprehensive risk assessment before taking medication, and develop an individualized treatment plan under the guidance of a professional physician.