司替戊醇能有效治病吗？

Introduction: Stipentol is indicated for the treatment of seizures associated with Dravet syndrome in patients taking clobazam who are 6 months of age or older and weigh 15 pounds or more. There is currently no clinical data to support the use of stiripentol alone in the treatment of Dravet syndrome.

Can the generic version of stiripentol also be effective in treating diseases?

On July 27, 2023, the official website of the China Food and Drug Administration showed that the generic dry suspension of Shijiazhuang No. 4 Pharmaceutical Co., Ltd. was approved for marketing in China, and the approved indications are: In combination with clobazam and valproate, it is indicated for the add-on treatment of refractory generalized tonic-clonic seizures in patients with severe myoclonic epilepsy of infancy (SMEI, Dravet syndrome) that cannot be adequately controlled by clobazam and valproate. The launch of generic drugs has given domestic children with Dravet syndrome more choices, and is expected to reduce treatment costs and improve drug accessibility.

The efficacy of generic stiripentol drugs is usually equivalent to that of the original drug, because they need to pass consistency evaluation to prove that there is no significant difference in quality and efficacy from the original drug before they can be approved for marketing by relevant departments. Therefore, it is possible that the generic version of stiripentol can also play an effective role in the treatment of Dravet syndrome and can also effectively treat the disease, which is better.

Prices of generic versions of stiripentol

The original stiripentol has not yet been marketed in China. Shijiazhuang No. 4 Pharmaceuticals’ stiripentol dry suspension has been approved, giving children with Dravet syndrome in China more choices.

Currently, we know that the generic stiripentol produced by Shijiazhuang No. 4 Pharmaceutical Co., Ltd. has been included in the medical insurance and enjoys medical insurance reimbursement. The winning bid price of the drug ranges from about 2550$ to 1500$. The price after reimbursement may be cheaper. The specific price needs to be calculated according to the local medical insurance reimbursement ratio.

Dosage forms and specifications of stiripentol

1. Capsules: 250mg is No. 2, pink, printed with "Diacomit" and "250 mg", 500mg specification is No. 0, white, printed with "Diacomit" and "500 mg".

2. Oral suspension: each contains 250mg or 500mg of stiripentol as a light pink fruit-flavored powder, packaged in a small packet.