癫痫药苯巴那酯的作用功效及用药注意事项简介

Introduction: Cenobamate is a new anti-epileptic drug that works through multiple mechanisms and has anti-convulsant effects. Phenobarate is a prescription drug and should be used under the guidance of a doctor. This article mainly talks about the effects, drug characteristics, precautions, and adverse reaction management of phenobarnate.

Efficacy

Phenobarnate inhibits the continuous flow of sodium ions into cells through voltage-gated sodium channels, reducing abnormal discharges of nerves.

As an allosteric modulator of non-benzodiazepine GABAA channels, it enhances the effect of GABAergic neurotransmitters, thereby inhibiting the excitability of nerves. Phenobarate is indicated for partial-onset epilepsy in adults and can effectively control the frequency and severity of epileptic seizures. In clinical trials, phebanate significantly reduced the number of seizures compared with placebo, and some patients achieved zero seizures.

Drug Features

Oral spray, easy to use, suitable for home or community emergency use.

It is highly effective and can quickly terminate epileptic seizures.

It is safe and does not cause respiratory depression or cardiovascular events.

Well tolerated and does not lead to drug resistance or dependence.

It has good compatibility with other anti-epileptic drugs and will not affect their efficacy or increase their adverse reactions.

Notes

1. Patients with hepatic insufficiency: For patients with mild to moderate hepatic insufficiency, the maximum recommended dose is 200 mg per day. Phenobarate is not recommended for patients with severe hepatic impairment.

2. Withdrawal of medication: It is not recommended that patients stop medication on their own. If discontinuation is necessary, the dose should be gradually reduced over at least 2 weeks to avoid the risk of increased seizure frequency.

3. Shortening of the QT interval: Phenobarate may shorten the QT interval in the electrocardiogram and increase the risk of sudden death and ventricular arrhythmia. Especially for patients with familial short QT syndrome, its use should be avoided.

4. Suicidal behavior and tendencies: During the use of phenoparate, patients should be monitored for suicidal thoughts or behaviors and/or any abnormal changes in mood or behavior.

5. Drug interactions: Pay attention to the interactions between phenobanate and other drugs, including drugs that may enhance the depressant effect of the central nervous system.

6. Pregnancy and lactation: There is currently insufficient data to indicate that there are developmental risks associated with the use of phenoparate in pregnant women. Adverse developmental effects have been observed in animal studies, so pregnant and lactating women should use it under the guidance of a physician after weighing the risks and benefits.

7. Medication for the elderly: Dosage selection for elderly patients should be cautious, usually starting from the low end of the dosing range.

8. Renal insufficiency: For patients with mild to moderate renal insufficiency, dose reduction should be considered. Phenobarate is not recommended if the patient is undergoing dialysis.

9. Medication contraindications: It is contraindicated for those who are allergic to any component of phenobarnate, and patients with familial short QT syndrome.

Adverse reaction management

When using, attention should be paid to possible side effects, such as drowsiness, dizziness, fatigue, double vision and headache. If serious adverse reactions occur, such as ataxia, nystagmus, dizziness, nausea, etc., you should contact your doctor immediately. Phenobarate may increase the risk of suicide and the patient's mental status should be closely monitored. Patients should avoid drinking alcohol and operating hazardous machinery while using phebanate until they become familiar with the effects of the drug.