氨己烯酸口服溶液用散的注意事项和用药禁忌概述

Introduction: Vigabatrin oral solution powder is mainly used to treat infantile spasms. It is also particularly effective for drug-resistant partial-onset epilepsy. When using vigabatrin oral solution powder, patients should be treated under the guidance of a doctor and follow the recommendations in the instructions. At the same time, doctors should inform caregivers of children on how to prepare and take the drug, and ensure correct use. This article mainly talks about the precautions, contraindications, drug interactions, pharmacological effects and adverse reactions of vigabatrin oral solution.

Notes

1. Permanent vision damage: Vigabatrin may cause permanent vision damage, and vision monitoring should be carried out regularly during treatment.

Patients with renal insufficiency: Dosage adjustment required.

2. Discontinuation of medication: If no obvious clinical effect is observed within 2 to 4 weeks of treatment, the medication should be stopped.

3. Pregnant and lactating women: Not recommended because it may cause harm to the fetus or nursing infant.

4. Medication in children: The safety and effectiveness of vigabatrin monotherapy in treating spasticity in children aged 1 month to 2 years old has been established, but it is not recommended for use in children under 1 month old.

5. Treatment of drug withdrawal: If you want to stop using vigabatrin oral solution powder, you should gradually reduce the dose instead of stopping the drug suddenly.

Contraindications

Contraindications are not clear, but it is contraindicated in pregnant and lactating women, patients with severe hepatic impairment, pulmonary hypertension associated with idiopathic pulmonary fibrosis, and systolic blood pressure <95 mm Hg at the beginning of treatment.

Drug Interactions

Vigabatrin may interact with other anti-epileptic drugs. For example, dosage adjustment may be required when combined with phenytoin, and related adverse reactions may be increased when combined with clonazepam. If you need to use other drugs while using vigabatrin oral solution powder, you should consult your doctor or pharmacist to avoid possible drug interactions.

Pharmacological effects

The pharmacological effect of vigabatrin oral solution powder is through specific and irreversible binding to GABA aminotransferase, resulting in an increase in the concentration of GABA in the brain, thereby exerting anti-epileptic effects. It is absorbed rapidly after oral administration, reaching the peak blood level 2 hours after taking it, and is mainly excreted in the urine.

Adverse reactions

During use, some adverse reactions may occur, such as drowsiness, fatigue, dizziness, depression, headache, confusion, etc. Patients may also experience weight gain and mild gastrointestinal discomfort. In children, excitement and anxiety may occur. Vigabatrin may cause irreversible concentric visual field defects. If serious or persistent adverse reactions occur, seek medical attention immediately.

When using vigabatrin oral solution powder, you should strictly follow your doctor's advice and read the drug instructions carefully. If any adverse reactions or discomfort occur, you should seek medical treatment promptly and inform the doctor of the drugs you are using.