喜保宁的功效和作用以及副作用一文解析

Introduction: Vigabatrin, also known as vigabatrin or Sabril, is an anti-epileptic drug mainly used to treat specific types of epilepsy. The mechanism of action of Vigabatrin is to irreversibly inhibit gamma-aminobutyric acid transaminase (GABA), thereby increasing the concentration of GABA in the central nervous system, reducing neural overexcitation, and helping to control epileptic seizures. This article mainly talks about the functions, efficacy, experimental efficacy, side effects and precautions of Vigabatrin.

Effects and effects

1. Anti-epileptic effect: Vigabatrin irreversibly inhibits γ-aminobutyric acid (GABA) aminotransferase (GABA-T), thereby increasing the concentration of GABA in the brain, reducing nerve excitability, and reducing the risk of epileptic seizures.

2. Adjuvant treatment of refractory complex partial epilepsy: Vigabatrin is suitable for adults and children aged 2 years and above with refractory complex partial epilepsy who have poor response to several alternative treatments.

3. Treatment of infantile spasms: Vigabatrin has potential therapeutic effect in treating infantile spasms. It can improve infant spasms and is suitable for children aged 1 month to 2 years old suffering from infantile spasms.

4. Reduce the frequency and intensity of epileptic seizures: Vigabatrin can reduce the frequency and intensity of epileptic seizures and improve the prognosis of patients.

Trial efficacy

1. Refractory complex partial epilepsy: In two multi-center, double-blind, placebo-controlled, parallel-group clinical studies on adult patients, Vigabatrin was proven effective as an adjuvant treatment. The study showed that 39% of patients taking Vigabatrin (3g/day) reduced the frequency of complex partial epilepsy seizures by 50% or more, while only 21% of patients in the placebo group achieved the same effect.

2. Infantile spasms: In two multicenter controlled studies, the effectiveness of Vigabatrin as a monotherapy for infantile spasms was confirmed. The study found a statistically significant difference in the overall percentage reduction in infantile spasms between the Vigabatrin group (68.9%) and the placebo group (17.0%).

Side Effects

Vibatrin has certain side effects, such as visual field defects, drowsiness, muscle hypotonia, weight gain, nausea, vomiting, diarrhea, etc. For side effects, if the symptoms are mild, they can usually be improved by adjusting the medication time. If the situation persists or worsens, it is recommended to communicate with your doctor, who may need to adjust the drug dosage or replace other drugs. Patients should pay close attention to their physical condition while taking the medicine, and if they have any discomfort or concerns, they should consult their doctor in time. Doctors will evaluate the severity of side effects based on the patient's specific situation and take appropriate treatment measures.

Precautions

When using Vigabatrin, pay attention to regular visual field examinations and do not adjust the dosage or stop the drug at will. Pregnant or lactating women should not use Vigabatrin. The elderly or patients with renal impairment should use Vigabatrin with caution under the guidance of a doctor and avoid driving vehicles or operating heavy machinery. During use, the doctor should be informed of all medications being used, including prescription drugs, over-the-counter drugs, vitamins and herbal supplements, to avoid potential drug interactions. If you develop serious side effects or allergic reactions while using Vigabatrin, such as rash, difficulty breathing, or facial swelling, you should stop taking the drug immediately and seek medical help.

During the use of Vigabatrin, patients should pay close attention to the occurrence of any adverse reactions and communicate with medical professionals in a timely manner in order to receive appropriate guidance and treatment.