喜保宁中文说明书及用法用量详解

Vigabatrin is an analogue of gamma-aminobutyric acid (GABA) and is used to treat patients who are refractory to other anti-epileptic drugs. Vigabatrin is not currently on the market in China, so many patients do not understand the instructions and usage and dosage of Vigabatrin. Below is the Chinese instruction manual and detailed explanation of usage and dosage of Vigabatrin compiled by Medical Companion Travel.

[Indications] Adjuvant treatment of anti-epilepsy. Vigabatrin can be used as an adjuvant treatment for partial seizures in refractory complex epilepsy. Vigabatrin can also be used to treat infantile spasms and Lennox-Gastaut syndrome. Vigabatrin is used in tardive dyskinesia.

[Dosage] Adults: The recommended dose is 3g per day, taken in divided doses. The dose should be increased according to the clinical effect at a rate of 0.5-1g per day to 4g per day (or 50mg/kg per day), which is effective for complex partial seizures of epilepsy (with or without generalized tonic-clonic seizures). Children: General usage: For children aged 3-9 years, the recommended dose is 1g per day, divided into 2 times; for older children, 2g per day, divided into 2 times. West syndrome: Average oral dose is 100 mg/kg daily (range 50-150 mg/kg).

[Adverse Reactions]: Common adverse reactions of Vigabatrin include fatigue, drowsiness, headache, dizziness, confusion and depression. Occasional aggressive behavior and psychosis (more common in patients with a history of psychosis and behavioral problems), memory loss, diplopia, weight gain, gastrointestinal disturbances, edema, and alopecia. Nystagmus, nervousness, agitation, ataxia, paresthesia, and tremor may also occur.

[Precautions] Peripheral neuropathy: Peripheral neuropathy occurs in adult patients and is manifested by numbness or tingling in the toes or feet, weakened vibration or position sensation in the distal lower limbs, or gradual loss of reflexes. Suicidal Ideation: Patients taking antiepileptic medications are at increased risk for suicidal ideation/behavior. Monitor changes in the patient's behavior and notify the doctor immediately if suicidal thoughts or symptoms of depression occur. Fetal Toxicity: Neonatal defects reported after use during pregnancy include: heart defects, limb defects, male genital malformations, fetal anticonvulsant syndrome, renal and ear malformations.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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