喜保宁的功效和作用都有哪些呢？

On August 21, 2009, the U.S. FDA approved Vigabatrin as a monotherapy for pediatric patients aged 1 month to 2 years old, where the potential benefits of infantile spasms outweigh the potential risk of vision loss, and as an adjuvant (additional) treatment for adult patients with refractory complex partial epilepsy (CPS). What are the effects and functions of Vigabatrin?

Efficacy and effects of Vigabatrin: Vigabatrin has anti-epileptic effects. Its mechanism of action is to irreversibly inhibit GABA aminotransferase (GABA-T) and increase the concentration of GABA in the brain to exert its effects. Clinical research results show that Vigabatrin is an effective and safe anti-epileptic drug for the treatment of children with severe epilepsy, and is also effective for epilepsy patients with intellectual disabilities.

Vigabatrin is an analog of gamma-aminobutyric acid (GABA). It can specifically bind to GABA aminotransferase and irreversibly, leading to an increase in GABA concentration in the brain, thus exerting anti-epileptic effects. Clinical research results show that vigabatrin is an effective and safe anti-epileptic drug in the treatment of children with severe epilepsy, and is also effective in epilepsy patients with intellectual disabilities. Vigabatrin tablets are absorbed rapidly after oral administration, and food does not affect its absorption rate. Peak plasma concentration is reached 2 hours after taking the drug, t1/2 is 5-7 hours, and a single dose is 1-3g. The pharmacokinetics show a dose-linear relationship, the apparent volume of distribution is about 0.8L/kg, and the relative bioavailability is 92±11%. Vigabatrin tablets are suitable for the treatment of intractable partial epilepsy, especially for intractable childhood epilepsy.

Vigabatrin is used as adjunctive therapy in patients who are refractory to other antiepileptic drugs, especially those with partial seizures (mainly used to control complex partial seizures). At present, Vigabatrin has not been launched in China, so patients in need can consult the medical companion and travel service for more information.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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