Latest prices for a box of different versions of larotrectinib announced

Introduction: With the advancement of medical technology and the growth of market demand, larotrectinib not only retains its excellent therapeutic effect, but its price system is also increasingly diversified to meet the needs of different patients. The following will give you a detailed introduction to the latest prices of different versions of larotrectinib, and an in-depth discussion of its possible central nervous system (CNS) effects and corresponding management strategies.

1. Overview of the latest prices of different versions of larotrectinib

1. Original drug

Germany's Bayer larotrectinib capsules: As the original developer of this drug, Germany's Bayer provides two specifications of capsules for patients to choose from. The 25mg 56-tablet specification is priced at 15,340$ per box, which is suitable for patients who require low-dose treatment; while the 100mg 56-tablet specification is priced at 52,000$ per box.

Germany's Bayer Oral solution: In order to facilitate the administration of specific patient groups (such as those with dysphagia), Germany's Bayer has also launched a 20mg/ml oral solution dosage form, with the price set at 18,228$ per box. This dosage form provides patients with a more flexible way of taking medication.

2. Generic drugs

Bangladesh Everest: The price of 100mg*30 tablets of generic drugs produced by Bangladesh Everest is 4520$ per box.

Bangladesh Yaopin International: Yaopin International, also from Bangladesh, has also launched larotrectinib generic drug in 100mg*30 capsules, with the price further reduced to 4,000$ per box.

Lucius, Laos: Larotinib generic drug 100mg*30 tablets from Lucius Pharmaceutical Company of Laos, the price is only 1950$ per box.

2. Central nervous system effects of larotrectinib

During the treatment of larotrectinib, some patients may experience a series of central nervous system adverse reactions, including but not limited to dizziness, cognitive impairment, mood disorders and sleep disorders. These effects can have a negative impact on patients' quality of life and even affect the safety of daily activities.

1. Dizziness: Dizziness is one of the more common adverse reactions during larotrectinib treatment, which may cause patients to feel unsteady or have blurred vision. Patients are advised to rest immediately when symptoms of dizziness occur and avoid activities that require a high degree of concentration.

2. Cognitive impairment: Some patients may experience cognitive impairment symptoms such as memory loss and distraction after receiving larotrectinib treatment. This may affect the patient's ability to work and study daily. Medical staff should pay close attention to changes in patients' cognitive functions and adjust treatment plans in a timely manner.

3. Mood disorders: Larotrectinib may also cause mood disorders, such as anxiety, depression, etc. These emotional changes not only affect the patient's mental health, but may also have a negative impact on the effectiveness of treatment. It is recommended that patients communicate their emotional changes with medical staff in a timely manner in order to obtain necessary psychological support and intervention.

4. Sleep disorder: Sleep disorder is another central nervous system adverse reaction worthy of attention during larotrectinib treatment. Patients may have difficulty falling asleep and decreased sleep quality. Medical staff should develop a personalized sleep management plan based on the patient's specific situation, such as adjusting medication time and providing a comfortable sleeping environment.