How long is larotrectinib effective

Introduction: Larotrectinib (Larotrectinib) While paying attention to its efficacy, issues such as the drug’s validity period, storage conditions, and drug safety cannot be ignored. Understanding this information is critical to ensuring safe and effective use of larotrectinib in patients. This article will elaborate on the validity period, storage requirements and overdose treatment methods of larotrectinib, and provide comprehensive medication guidance for patients and their families.

Validity period and storage conditions

Validity period:The validity period is usually 24 months, that is, starting from the date of production, under specified storage conditions, the drug can maintain its original quality and efficacy for up to two years. Therefore, patients should carefully check the production date and expiration date of the medicine before use to ensure that it is taken within the expiry date.

Capsule storage: For larotrectinib in capsule form, it is recommended to store it at a room temperature of 20°C-25°C, avoiding direct sunlight and moisture. The manufacturer also allows transportation within a temperature range of 15°C-30°C to ensure the stability of the drug during transportation. However, to maintain optimal quality, patients should transfer their medicines to a suitable storage environment as soon as possible after receipt.

Oral solution storage: Oral solution dosage form of larotrectinib requires more stringent storage conditions, that is, it should be stored inStore under refrigerated conditions at 2°C-8°C and cannot be frozen. Freezing may cause changes in the components of the solution, affecting the efficacy and safety of the drug. Therefore, patients need to be equipped with appropriate refrigeration equipment and regularly check the refrigeration temperature to ensure that the drug storage environment meets the requirements.

How to deal with overdose

Although larotrectinib was well tolerated during treatment, there is a risk of overdose with any drug. In the event of larotrectinib overdose, the following measures should be taken immediately:

Emergency medical assistance: First, contact medical emergency services or go to the nearest medical facility quickly and inform the doctor that the patient has overdosed on larotrectinib. The doctor will evaluate the degree of poisoning and take corresponding treatment measures based on the patient's specific situation.

Observation and monitoring: While waiting for medical assistance, family members should closely observe the patient's vital signs, such as heart rate, respiration, blood pressure, etc., and whether there are poisoning symptoms such as nausea, vomiting, dizziness, and coma. This information is critical for doctors to assess the condition and formulate treatment plans.

Supportive treatment: Depending on the patient's degree of poisoning and clinical manifestations, doctors may take measures such as gastric lavage, catharsis, and diuresis to accelerate drug excretion and reduce drug absorption and distribution in the body. They may also provide necessary life support treatment, such as respiratory support, circulatory support, etc., to maintain the stability of the patient's vital signs.

Follow-up follow-up: After the patient is out of danger, close follow-up is still required to monitor the patient's liver and kidney function, blood routine and other indicators, as well as whether there are delayed adverse reactions. The doctor will adjust the treatment plan according to the patient's recovery to ensure that the patient fully recovers.