How to treat adverse reactions caused by Capmatinib?

Introduction: Capmatinib is a kinase inhibitor used to treat adults with metastatic non-small cell lung cancer whose tumors have mutations that cause MET exon 14 skipping. The most common adverse reactions are peripheral edema, nausea, fatigue, vomiting, dyspnea, and decreased appetite.

1. Systemic diseases: edema, musculoskeletal pain, fatigue, fever, weight loss.

2. Gastrointestinal diseases: nausea, vomiting, constipation, diarrhea.

3. Respiratory system, chest and mediastinal diseases: cough, dyspnea, infectious pneumonia.

4. Skin and subcutaneous tissue diseases: rash, eczema, erythema multiforme, macular rash, dermatitis, erythematous rash, pustular rash

5. Nervous system diseases: dizziness, vertigo, headache.

Measures for the adverse reactions of Capmatinib

1. Nausea and vomiting: You can try taking Capmatinib before or after meals, or take it with food to reduce the symptoms of nausea and vomiting. If symptoms are severe or persistent, you should consult your doctor. Anti-nausea medications may be needed to relieve symptoms.

2. Diarrhea: Maintain adequate fluid intake and avoid irritating foods and beverages, such as coffee, spicy foods or high-fiber foods. If diarrhea is severe or persists for a long time, the dosage may be adjusted or other treatment measures may be given under the guidance of a doctor.

3. Peripheral edema: Mild edema may not require special treatment, but if the edema is severe or persistent, drug treatment or other interventions may be required.

4. Fatigue: Ensure adequate rest, adjust daily activities and workload, and consult a doctor for help when necessary.

5. Poor appetite and weight loss: Try to eat small and frequent meals and choose highly nutritious foods. If the problem is severe, guidance from a nutritionist or medication may be needed.

6. Skin abnormalities: If symptoms such as skin redness, itching, rash, etc. occur, the doctor should be notified in time for treatment. Keep the skin clean and hygienic during medication.

Patients should maintain close communication with their doctors while using capmatinib and report any adverse reactions in a timely manner so that doctors can adjust the treatment plan according to the patient's specific situation. When dealing with adverse reactions, you should follow the professional guidance of your doctor and do not adjust the drug dosage or stop treatment on your own.