What are the side effects and specific treatment measures of Yiluake Tablets (Qixinke)?

The side effects of Yiruake Tablets (Qixinke) mainly include nausea, vomiting, diarrhea, hyperuricemia, hypercholesterolemia, abnormal liver function, etc. Most side effects can be improved by reducing the dosage or suspending the medication, and symptomatic treatment.

About Iruplinalib (ALK+) or ROS1-positive (ROS1+) non-small cell lung cancer (NSCLC).

In June 2023, Yiruak Tablets (Qixinke) was approved in China for the treatment of patients with locally advanced or metastatic ALK+ NSCLC whose disease has progressed after previous crizotinib treatment or who are intolerant to crizotinib. Compared with crizotinib (Xalkori), treatment with Iluac (Xalkori) improved progression-free survival (PFS) and intracranial control in patients with locally advanced or metastatic ALK-positive non-small cell lung cancer.

Side effects of Yiluake Tablets (Qixinke)

1. Gastrointestinal diseases: such as nausea, vomiting, diarrhea, etc., are one of the common side effects of Yiluake Tablets.

2. Skin and subcutaneous tissue diseases: Yiruake Tablets can cause skin allergic reactions and other skin problems, such as rash, erythema, itching, etc.

3. Hyperuricemia: Yiluak tablets may cause an increase in uric acid levels in the blood.

4. Hypercholesterolemia: Yiruake Tablets may cause cholesterol to rise.

5. Abnormal liver function: Yiluak Tablets is hepatotoxic and may lead to abnormal liver function, such as ≥ grade 3 elevation of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) (> 5 × ULN) with total bilirubin ≤ 2 × ULN.

6. Other side effects: high blood pressure, elevated triglycerides, etc.

Specific measures to deal with side effects

1. Abnormal liver function: Pay attention to monitoring liver function during medication. If abnormality occurs, treatment should be suspended in a timely manner until it returns to baseline level or ≤1 level, and treatment should be continued according to the dose reduction plan.

2. Nausea, vomiting, and diarrhea: Eat a light diet, drink plenty of water to replenish moisture, and take antiemetic or anti-nausea drugs as directed by your doctor if necessary.

3. Rash: Keep the skin clean and hygienic, avoid excessive scratching to avoid infection, and avoid using irritating skin care products.

4. Hypertension: Suspend treatment until recovery to level ≤ 1, then resume medication at the original dose. If recurrence occurs, continue treatment at a reduced dose or permanently discontinue treatment.

Usage and Dosage of Yiruake Tablets

The recommended dose for adults is 60mg on days 1-7, once a day. Starting from the eighth day, take 180 mg once a day on an empty stomach in the morning. Yiluaq tablets can be taken with or without food, and it will not affect the efficacy of the drug.

Summary

The above side effects treatment measures are for reference only, and the specific guidance of the doctor should be followed. If any adverse reactions occur after taking the medication, patients should communicate with their doctor promptly to receive appropriate medical advice and treatment.

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