Can dacomitinib be stopped if the rash is severe? What will happen if it is stopped?

Patients with severe rash can stop taking dacomitinib under the guidance of a doctor and resume taking the drug after their symptoms improve.

After stopping dacomitinib, the patient's rash symptoms will be improved to a certain extent, but it may also affect the treatment effect, disease control, etc. Therefore, during the withdrawal period, it is recommended to closely observe the patient's condition changes and make next treatment decisions under the guidance of a doctor based on the actual situation.

Can dacomitinib be discontinued if the rash is severe?

is an irreversible inhibitor of the second-generation epidermal growth factor receptor/Her-2/Her-4 tyrosine kinase and can be used as a first-line treatment for patients with advanced non-small cell lung cancer with EGFR Ex21L858R and Ex19del mutations.

However, patients may also experience some adverse reactions during dacomitinib treatment, including rash. If the patient develops a severe rash, discontinuation of the drug may be considered. If the severity is Grade 2 or higher, your doctor will usually recommend discontinuing the medication until the rash reduces to Grade 1 or below.

Skin rash treatment measures

1. Consult a doctor in time: If the patient finds that he has a rash during treatment, he should consult a doctor in time, and the doctor will evaluate the severity of the rash and handle it under the guidance of the doctor.

2. Daily care: If a rash occurs during dacomitinib treatment, the skin should be kept clean and dry, and avoid scalding with hot water and wiping with rough objects. Try to wear loose, soft cotton clothing to reduce friction on the skin. At the same time, you should pay attention to sun protection, avoid exposure to strong sunlight, take sun protection measures when going out, and use mild and non-irritating skin cleansers and moisturizers.

3. Drug treatment: When a mild rash occurs, patients can follow the doctor's advice to use mild skin care products, topical antibiotic ointments, and topical hormone drugs to reduce the inflammatory reaction. Oral antihistamines can be taken for relief if necessary.

4. Dose adjustment and retreatment: If the patient's rash and other symptoms are relieved, it can be decided under the guidance of a doctor based on the patient's specific situation whether and how to resume dacomitinib treatment, which may include reducing the dose or restarting treatment at a lower dose.

5. Alternative therapy: For patients with severe rash who cannot tolerate dacomitinib, doctors may choose alternative drugs, such as another EGFR inhibitor with less side effects on the patient, or adjust the combination medication regimen to reduce adverse reactions such as rash.

What will happen if dacomitinib is stopped?

1. Symptom reduction: Skin rash caused by the drug is a side effect of the drug. After stopping dacomitinib, the rash and other related skin symptoms will usually gradually reduce or even disappear.

2. Treatment interruption: Discontinuation of dacomitinib means interruption of treatment, which may affect the continuity and effectiveness of treatment for cancer patients being treated with dacomitinib.

Other side effects of dacomitinib

The most common adverse reactions during dacomitinib treatment are dry skin, cough and itching, weight loss, paronychia, stomatitis, loss of appetite, hair loss, diarrhea, and rash.

Summary

It is recommended that patients should strictly follow the doctor's instructions during treatment with dacomitinib and should not adjust the dose or stop the drug without permission. At the same time, if any side effects occur, you should seek medical treatment in time and deal with them to prevent the side effects from worsening and endangering your health.

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