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Introduction: Naldemedine is a specific drug for the treatment of opioid-induced constipation (OIC). The cost of its treatment is a key concern of patients. This article will provide patients with a comprehensive cost reference from three aspects: medication dosage, specific cost structure, and medication for special groups.

How many boxes of Nadimedine per treatment course

The dosage of treatment should be calculated based on the treatment cycle and specifications.

Standard treatment plan

The recommended dose for adults is 0.2mg taken orally once a day. Based on a 4-week course of treatment, 28 days of medication are required.

Large packaging selection

When choosing the specification of 0.2mg*50 tablets, one box can satisfy 1.78 standard courses of treatment. Patients undergoing long-term treatment can choose this specification, which is cost-effective.

Small package selection

The 0.2mg*14 tablets are suitable for short-term trials. One box just meets the needs of 2 weeks of medication. Patients who are taking medication for the first time or are unsure of the efficacy can choose small packages first.

The specific number of treatment boxes needs to be determined based on the patient’s individual situation and the doctor’s recommendations.

How much does a course of Nadimedine cost?

The cost of a course of Nadimedine varies depending on specifications and purchase channels.

Large packaging cost

The price of 0.2mg*50 tablets is about US$520. Based on the standard course of treatment, the cost for four weeks is about US$291.

Small packaging cost

The price of 0.2mg*14 tablets is about US$173. A 4-week course of treatment requires 2 boxes, and the total cost is about US$346. The larger package is 18.9% more expensive.

Long-term treatment costs

Based on one year of continuous treatment, the annual cost of using a large package is approximately US$3,796, with an average monthly cost of US$316, and the annual cost of a small package is approximately US$4,498.

Drug prices will fluctuate with the exchange rate and purchasing channels. The prices are for reference only. Patients who take medicine for a long time are recommended to choose large packaging to save costs.

Usage of naldimedine in special populations

Special populations need to pay special attention to dose adjustment when using naldimedine.

Patients with hepatic impairment

There is no need to adjust the dose for patients with mild liver impairment. For patients with moderate to severe impairment, it is recommended to start with 0.1 mg and adjust to 0.2 mg based on response.

Patients with renal insufficiency

No adjustment is required for patients with mild to moderate renal impairment. For patients with severe renal impairment (eGFR<30), the recommended dose is halved to 0.1 mg daily.

Elderly patients

Elderly patients over 65 years old do not need routine dose adjustment, but due to the possibility of decreased liver and kidney function, it is recommended to start with a low dose and titrate slowly.

Monitoring should be strengthened for special groups of people during medication, and medication reactions should be reported to doctors in a timely manner.