纳呋拉啡用于什么止痛？

Nalfuraphine can be used for pain-related conditions such as uremic pruritus. However, nalfurapine is not a drug specifically used for analgesia. It is mainly used to improve pruritus in patients with chronic liver disease and peritoneal dialysis patients.

About nalfurapine

On July 5, 2023, Toray Industries Co., Ltd. in Tokyo, Japan, announced that its nalfurapine hydrochloride orally disintegrating tablets have been approved by the National Medical Products Administration of China (NMPA). The company developed this anti-itch drug for hemodialysis patients who find that existing itch therapies and therapies are not effective enough to improve itch in hemodialysis patients who find that existing therapies or therapies are not effective.

Indications of nalfurapine

It is a selective kappa-opioid receptor (KOR) agonist that exerts its antipruritic effect through a new mechanism of action that is completely different from existing antihistamines or anti-allergic drugs. Nafurafine is mainly used to treat pruritus in hemodialysis patients, especially when existing treatments are not effective. In addition, nalfurapine is also used to improve pruritus in patients with chronic liver disease and peritoneal dialysis patients.

What is nalfuraphine used for for pain relief

The analgesic effect of nalfurapine is not its primary use, but it does have pain relief potential. In some studies, nalfurapine has been found to enhance the biological effects of mu-opioid receptor (MOR)-targeted analgesics. This means that nalfurapine may help enhance the analgesic effects of other opioids, especially when dealing with pain-related conditions such as uremic pruritus.

However, although nalfurapine, as an opioid, has analgesic potential, in actual clinical applications, it is mainly used to treat itching symptoms rather than as the main analgesic drug.

Nalfuraphine dosage and administration

The usual adult dose of nalfurapine is 2.5 µg once daily, which can be taken after dinner or before bed. The maximum dose is 5 µg once daily.

Nafuraphine can be taken with or without water, which is convenient for older adults and others who have difficulty swallowing pills or who have fluid restrictions and can help improve medication compliance.

The price of nalfuraphine

The reference price of a box of 2.5ug*14 tablets is about 470$-800$. The reference selling price for a box of 2.5ug*140 tablets is relatively expensive, probably between 4250$-5000$.

Summary

Before using nalfurapine, you should consult a doctor and strictly follow the doctor's instructions to avoid dependence and other potential side effects. During medication, you should avoid eating large amounts of high-potassium foods, such as spinach, water spinach, seaweed, kelp, carrots, bananas, mangoes, etc. Patients with stable symptoms are advised to exercise moderately and lightly every day, go to bed early and get up early, and maintain a regular schedule.

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