纳地美定(Naldemedine)的疗效好吗,怎么购买？

Naldemedine has good efficacy and can be purchased through hospital pharmacies, clinics, retail pharmacies, online pharmacies, drug agents, medical service institutions, purchasing abroad, consulting patients, etc.

Indications for naldimedine

Naldimedine is an opioid antagonist indicated for the treatment of chronic non-cancer pain in adult patients with opioid-induced constipation, including patients with chronic pain related to previous cancer or its treatment.

Efficacy of Naldemedine

Purpose of the study

Initiation of peripherally acting μ-opioid receptor antagonists (PAMORAs) should be considered after 2 weeks when conventional laxatives have failed to achieve adequate efficacy, and affected patients should be evaluated every 2 weeks thereafter. Investigate the use of naldimedine in combination with other laxatives in the emergency setting.

Research Methods

The study evaluated changes in the average daily number of bowel movements and the incidence of diarrhea in the first 7 days after taking naldimedine compared with before taking naldimedine in 93 hospitalized patients who received at least 4 doses of naldimedine.

Study results

Compared with before taking naldimedine, the group taking naldimedine, magnesium oxide and another laxative had higher daily bowel movements in the first 7 days after taking naldimedine than the group taking only naldimedine. The incidence of diarrhea was significantly higher in the naldimedine, magnesium oxide, and another laxative group, and in the naldimedine and another laxative other than magnesium oxide group, than in the naldimedine only group.

Study conclusion

The use of naldimedine alone or in combination with magnesium oxide should be considered. Naldemedine reduces the impact of opioids on the enteric nervous system by acting on peripheral opioid receptors, thereby regulating intestinal peristalsis and secretion activities and fundamentally solving the problem of constipation. Clinical trials have shown that patients using naldimedine reported good improvements in constipation symptoms without affecting the analgesic effect of opioids.

How to purchase Naldemedine

1. Hospital pharmacies: Naldemedine is temporarily unavailable in inland areas, but it can be treated in hospitals in Taiwan, China. Doctors can prescribe Naldemedine according to the needs of the condition, and then Naldemedine can be purchased in the hospital pharmacy.

2. Clinic: You can go to a clinic in Taiwan, China, or buy Nadimedine after issuing a prescription.

3. Retail pharmacies: Some retail pharmacies in Taiwan, China may sell Nadimedine. You can go to the drugstore to ask if Nadimedine is available.

4. Online pharmacies: Some pharmacies on the Internet may also sell Nadimedine. When shopping online, make sure to purchase from a regular, reputable platform and have a doctor's prescription.

5. Drug agents: If Nadimedine cannot be purchased in your area, you can contact the drug agent to learn about purchase channels.

6. Medical service institutions: There are some domestic medical service institutions that can help purchase drugs that are temporarily unavailable or in short supply in China. You can consult their customer service staff to place an order, and then obtain Nadimed by mail.

7. Purchase abroad: You can purchase Nadimedine at national hospitals or pharmacies where Nadimedine is already on the market.

8. Consult patients: You can consult patients you know who are taking Nadimedine treatment and ask them where they bought Nadimedine, which can be used as a reference.

Price of Nadimedine

1. 0.2mg*50 tablets: the reference price of a box is between 3790$-5000$.

2. 0.2mg*14 tablets: the reference price of a box is between 1260$-2000$.

The price is also subject to changes in exchange rates, and the specific price should be subject to actual conditions.

Summary

When choosing a purchase channel, it is recommended that patients make a choice based on their own situation and needs. If they need to take naldimedine, they should follow the doctor's guidance to take the drug correctly and understand the correct medication method and possible side effects.

References:

Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2022 Jun 24:bmjspcare-2022-003685. doi: 10.1136/spcare-2022-003685. Epub ahead of print. PMID: 35750467.

Related hot article recommendations: