舍曲林治疗效果怎么样？

Post-schizophrenia depression is generally treated with antipsychotic drugs, which can improve depressive mood, but single drug treatment is ineffective. The main component has an inhibitory effect on the reuptake of 5-hydroxytryptamine in the central nervous system, which is conducive to the increase and accumulation of 5-hydroxytryptamine substances in the synaptic gap. It has a good antidepressant effect, has no significant impact on epinephrine and dopamine in the body, and has high safety. Clinical studies have confirmed that post-schizophrenia depression has a high incidence rate of about 20%, and clinically most patients have depressive symptoms.

Seventy patients with residual schizophrenia who were diagnosed and treated were selected and divided into a combination treatment group (35 cases, treated with sertraline hydrochloride tablets and risperidone) and a control group (35 cases, treated with risperidone). The positive, negative and total scores of the Positive and Negative Symptom Scale (PANSS), and the Mini-Intelligence Scale (MMSE) were compared between the two groups before treatment and 6 months and 12 months after treatment.

Results The PANSS in both groups was positive and negative 6 months after treatment, the total score was lower than before treatment, and the MMSE score was higher than before treatment (P<0.05). The positive, negative, and total PANSS scores of the two groups 12 months after treatment were lower than those 6 months after treatment and before treatment, and the MMSE scores were higher than those 6 months after treatment and before treatment (P<0.05). Six months after treatment, the combined treatment group had PANSS positivity and total score lower than the control group, and MMSE score higher than the control group (P<0.05); 12 months after treatment, the combined treatment group had PANSS positivity and negative, the total score was lower than the control group, and the MMSE score was higher than the control group (P<0.05).

It is concluded that sertraline tablets combined with risperidone can effectively reduce the PANSS score and increase the MMSE score of patients with residual schizophrenia, and has a brain-protective effect on patients with residual schizophrenia.

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