雷美替胺(Ramelteon)如何用药

Ramelteon is a non-benzodiazepine hypnotic drug mainly used for insomnia characterized by difficulty falling asleep.

How to use Ramelteon

1. Standard dosage and usage

(1) Adult dosage: 8 mg each time, once a day.

(2). Taking time: should be taken within 30 minutes before planning to fall asleep.

(3) How to take: Swallow the tablet whole, do not break or chew it.

(4). Dietary precautions: Avoid taking it with high-fat foods or immediately after meals, otherwise it will affect drug absorption.

2. Applicable people and treatment courses

Applicable to adult insomnia patients, especially those who have difficulty falling asleep.

The longest clinical study time is 6 months. If symptoms do not improve after 7-10 days of taking the drug, the cause should be re-evaluated.

3. Medication for special groups

(1) Patients with hepatic insufficiency: Use with caution in patients with moderate hepatic insufficiency, and contraindicated in patients with severe hepatic insufficiency.

(2) Patients with renal insufficiency: No dosage adjustment is required.

(3) Elderly people: The dosage is the same as that of young adults, no adjustment is required.

(4) Children and adolescents: Safety and effectiveness have not been established and use is not recommended.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Precautions before taking Ramelteon

1. Screening of contraindications

(1) It is prohibited for those who are allergic to Ramelteon or any of its ingredients.

(2) Those who have experienced angioedema (such as tongue and throat swelling) after use are prohibited from using it again.

(3) It is prohibited to use it in combination with fluvoxamine, as it will significantly increase the plasma concentration of ramelteon.

2. Drug interaction assessment

Before use, you should inform your doctor of all the drugs you are taking, including prescription drugs, over-the-counter drugs and health care products

Precautions after taking Ramelteon< /h2>

1. Monitoring of common adverse reactions

In clinical trials, adverse reactions with an incidence rate of ≥3% and higher than placebo include: drowsiness, dizziness, fatigue, nausea, and worsening insomnia. If the above symptoms persist or worsen, you should seek medical treatment in time.

2. Serious adverse reactions

(1) Severe allergic reactions: such as throat swelling, difficulty breathing, vomiting, etc. Seek medical attention immediately.

(2) Complex sleep behaviors: including "sleep driving", eating in dreams, making phone calls, sexual intercourse, etc., which cannot be recalled afterwards. If this occurs, stop taking the medicine immediately and inform your doctor.

(3) Abnormal mental behavior: such as hallucinations, agitation, worsening of depression, suicidal thoughts, etc., which require immediate evaluation.

(4) Endocrine effects: It may lead to a decrease in testosterone and an increase in prolactin, which may manifest as loss of sexual desire, irregular menstruation, milk secretion, etc. You should consult a doctor for hormone testing.

3. Daily activities and behavioral warnings

(1) After taking the medicine, you should stay in bed as soon as possible and avoid activities that require concentration, such as driving and operating machinery.

(2). You may still feel sleepy the next day, so you need to make sure you are fully awake before engaging in high-risk activities.

(3). It is forbidden to drink alcohol while taking the medicine.