莱博雷生一次能囤几盒?多少钱?

Lebrasin is a drug for the treatment of insomnia. Its reasonable use involves purchase quantity control, awareness of the price system and medication specifications for special groups. Patients need to formulate a medication plan under the guidance of a physician. This article will discuss it from three dimensions: restrictions on the quantity of medicines stored, market price analysis, and adjustment of medicines for special groups.

How many boxes of Lebrasin can be stocked at one time

In principle, the dosage of prescription drugs for chronic diseases should not exceed 30 days' dosage. The amount of a single prescription is usually controlled at 1-2 boxes (30 tablets/box). The specific purchase quantity needs to be determined comprehensively based on the treatment stage, dosage specifications and storage conditions.

Quantity limit stipulated in the policy

The psychiatry department of the hospital usually prescribes 1 box (30 tablets) for first-time patients. This can be extended to 2 boxes for follow-up patients after evaluation. The 10mg high-dose version is limited to 1 box due to less clinical use.

Conversion between dosage and stored medicine

Based on the average daily dosage of 5mg, one box of 30 tablets can meet the 30-day standard treatment course. When the 2.5 mg strength is used in the dose adjustment phase, double dose use may result in a 15-day dosage requirement. Medical institutions recommend that the interval between each follow-up visit should not exceed 45 days, corresponding to a maximum stockpile of 3 boxes of medicine.

How much does Lebraxen cost?

The price system of Lebraxen shows obvious dose correlation, and there are differences in prices for different specifications. The price is for reference only.

Drug Price

Japan’s Eisai version of Lebraxen is mainly available in three specifications on the market: 2.5mg, 5mg and 10mg. The price of the 2.5mg specification is about US$77 per box; the price of the 5mg specification of 100 tablets is about US$117 per box; and the price of the 10mg specification is relatively high, about US$165 per box.

Factors affecting price

Drug prices may change due to factors such as drug specifications, purchase channels, exchange rate changes, etc. Patients are advised to refer to the actual price at the time of purchase.

Dose of Lebraxen for special populations

Dosage adjustment and close monitoring of Lebraxen are required for patients with special physiological conditions. Pharmacokinetic studies have shown that drug clearance is reduced in patients with hepatic insufficiency, requiring a stepwise dose adjustment scheme.

Use for patients with abnormal liver and kidney function

The starting dose for patients with Child-Pugh Class B liver damage is reduced to 2.5 mg, and the maximum daily dose does not exceed 5 mg. It is contraindicated for patients with Class C liver failure. Patients with renal insufficiency (eGFR <30ml/min) do not need to adjust the dose, but daytime sleepiness needs to be monitored. The administration time for hemodialysis patients should be adjusted to 4 hours after the end of dialysis.

People with special physiological conditions

Contraindicated in pregnant women. Animal experiments show that 10mg/kg dose can cause fetal bone deformities. Breastfeeding needs to be suspended during lactation. The starting dose for elderly patients over 75 years old is limited to 2.5 mg. The risk of falling in the morning increases by 2.3 times and requires intensive care.

Patients with moderate to severe obstructive sleep apnea (AHI ≥ 15) need to be treated with continuous positive airway pressure. The frequency of nighttime blood oxygen saturation monitoring in patients with chronic obstructive pulmonary disease (COPD) should be increased to three times a week.