莱博雷生有哪几个版本?分别多少钱?

Leborexan is a dual orexin receptor antagonist used to treat insomnia, helping patients improve sleep quality by regulating the sleep-wake cycle. Lebrasin produced by Japan Eisai Company is currently the most widely used version in the world. Its different specifications and price information are of great reference for patients' treatment choices. This article will analyze the version classification, price difference and efficacy of Lebrasen to provide patients with a practical guide.

What are the versions of Lebraxen?

Japanese Eisai Company currently has three dosage specifications, namely 2.5mg, 5mg and 10mg tablets. The three versions are designed to meet the individual needs of different patients. Dosage selection is usually based on the patient's symptom severity, age and body metabolism, and the doctor will adjust the medication plan according to the patient's specific condition.

Specifications and Applicable Populations

The 2.5mg specification is usually used as the starting dose and is suitable for patients with mild insomnia or drug sensitivity; 5mg is the conventional treatment dose for most patients, which can balance efficacy and safety; 10mg is used for patients with more severe symptoms or insufficient response to low doses. Tablets of different specifications also have different packaging sizes. For example, the 5mg version is usually packed in 100 tablets, which facilitates long-term medication management.

Dose adjustment and medication suggestions

Patients usually start with a low dose when starting treatment and gradually adjust it according to the sleep improvement effect. For older patients or those with impaired liver function, doctors may recommend a lower initial dose to reduce the risk of adverse reactions. The medication time must be strictly followed before bedtime to avoid drowsiness affecting normal activities the next day.

How much do the different versions of LeboRasen cost?

According to market data in 2025, the price of the Japanese Eisai version of LeboRasen varies with dosage and packaging specifications. The 2.5mg specification costs about US$77 per box, the 5mg (100 tablets) per box is about US$117, and the 10mg specification costs about US$165. The price difference is mainly due to the content of active pharmaceutical ingredients, production costs and market supply and demand.

Core factors of price differences

In terms of production costs, high-dose specifications (such as 10mg) require higher raw material inputs and quality control standards, resulting in an increase in unit prices. The impact of packaging quantity on the total price is reflected in the 100-piece package design of the 5mg specification. The average cost of a single piece is lower than that of small-package products. In addition, the circulation costs and import tariffs in different regions will also affect the terminal selling price.

Drug Purchasing Channels and Economic Choices

Purchasing Lebrasin in Japan can be obtained directly through prescriptions from medical institutions, and the price is relatively transparent. International patients need to purchase through compliant cross-border pharmacies or authorized dealers, and will need to bear additional logistics and customs fees. For patients who require long-term medication, it is more economical to choose large packaging specifications (such as 5mg/100 tablets), which can reduce the cost of single-day treatment.

Efficacy of leborexan

Leborexan selectively blocks orexin receptors and prolongs the deep sleep stage of non-rapid eye movement sleep, thereby improving sleep maintenance. Its clinical research data shows that the average time it takes for patients to fall asleep is shortened, the number of nighttime awakenings is reduced, and the cognitive function of the next day is not significantly affected.

Mechanism of action and clinical advantages

Compared with traditional benzodiazepines, Leborexen directly acts on the orexin system of the hypothalamus, reducing residual effects and the risk of dependence the next day. In phase III clinical trials, after 4 weeks of continuous use, most patients' subjective sleep quality scores improved.

Long-term efficacy and safety data

The 12-month extended study showed that leborexan maintains the efficacy with high stability and no increase in drug resistance.

Common adverse reactions of leborexan include mild headache and dry mouth, and the incidence of serious side effects is low. The safety profiles of different dose versions are similar, and increasing the dose does not significantly increase the risk of adverse reactions.