德国拜耳利伐沙班的作用

The domestic trade name is Xarelto, produced by the German company Bayer and approved for marketing in my country in 2009. It is an oral drug. Rivaroxaban is primarily used to treat deep vein thrombosis and pulmonary embolism in adults to reduce the risk of recurrence. In addition, it can prevent venous thrombosis in adult patients undergoing elective hip or knee replacement surgery, and can be used in patients with non-valvular atrial fibrillation to reduce the risk of stroke and systemic embolism.

The role of Rivaroxaban from Bayer in Germany: Rivaroxaban blocks the coagulation waterfall and prevents thrombosis by binding to factor Xa and inhibiting its action. Factor Xa is a key link in the intrinsic and extrinsic coagulation pathways. If factor Xa doesn't work properly, the blood clotting process won't work.

Eisenberg MJ et al. meta-analyzed five randomized controlled studies (a total of 23,063 patients were included, including 3,967 cases of deep vein thrombosis, 14,264 cases of non-valvular atrial fibrillation, and 3,967 cases of acute symptomatic pulmonary embolism, all taking rivaroxaban for ≥1 month). The results found that compared with vitamin K antagonists, , rivaroxaban did not increase the composite endpoint of major bleeding and clinically relevant bleeding (RR: 0.99, confidence interval: 0.93-1.06), and, in the rivaroxaban group, fatal bleeding events were significantly reduced (RR: 0.48, confidence interval: 0.31-0.74).

Compared with warfarin, patients do not need to routinely detect coagulation indicators while using rivaroxaban, making it more convenient to use. The treatment of patients with venous thrombosis is of great significance.

Finally, let’s learn about some of the leading manufacturers, Bayer in Germany. In 1863, Bayer AG was founded in Germany by Friedrich Bayer. Polymers, medicine and health care, chemicals and agriculture are Bayer's four pillar industries. It is also Germany's largest industrial group.

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