利伐沙班治疗静脉血栓效果怎样？

Xarelto has been approved in more than 100 countries around the world and has been successfully marketed by Bayer in more than 75 countries. In June 2009, rivaroxaban was officially launched in China under the trade name Xarelto. It is used to prevent or reduce the formation of blood clots, deep vein thrombosis (DVT) and pulmonary embolism (PE) after hip or knee replacement surgery. Today we will learn more about the effect of rivaroxaban in treating venous thrombosis? A newly published study shows that the new anticoagulant drug rivaroxaban from Bayer Healthcare of Germany can effectively reduce the formation of venous thrombosis in patients after major orthopedic surgery, and its efficacy is better than the current standard treatment of enoxaparin. Eisenberg MJ et al. meta-analyzed five randomized controlled studies (a total of 23,063 patients were included, all taking rivaroxaban for ≥1 month, including 14,264 cases of non-valvular atrial fibrillation, 3967 cases of deep vein thrombosis, and 3967 cases of acute symptomatic pulmonary embolism). The results showed that compared with vitamin K antagonists, rivaroxaban Xarelto did not increase the composite endpoint of major bleeding and clinically relevant bleeding (RR: 0.99, confidence interval: 0.93-1.06), and in the rivaroxaban group, fatal bleeding events were significantly reduced (RR: 0.48, confidence interval: 0.31-0.74).

A foreign study shows that when the plasma concentration of rivaroxaban ng/ml, pure endovascular therapy was performed. In this study, measurement of plasma levels of rivaroxaban enabled treatment of nearly one-third of patients who were originally considered ineligible for emergency intravenous thrombolysis. In addition, no bleeding events occurred in any of the 114 patients taking rivaroxaban in this study.

Rivaroxaban Xarelto is a highly selective, oral drug that directly inhibits factor xa. By inhibiting factor xa, the endogenous and exogenous pathways of the coagulation cascade can be interrupted, and the generation of thrombin and thrombosis can be inhibited.

The above is the content of the treatment effects of Xarelto, I hope it can help you!

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