利伐沙班拜瑞妥说明书

Xarelto Instructions

Generic name: Rivaroxaban

Product name: Xarelto

Full names: Rivaroxaban, Xarelto

Indications:

Rivaroxaban Xarelto is mainly used to treat venous thrombosis in adults: 1. It is used in adult patients undergoing elective hip or knee replacement surgery to prevent venous thrombosis (VTE). 2. Used to treat venous thrombosis (DVT) in adults and reduce the risk of DVT recurrence and pulmonary embolism (PE) after acute DVT. 3. For use in adult patients with nonvalvular atrial fibrillation who have one or more risk factors (e.g., congestive heart failure, hypertension, age ≥75 years, diabetes, history of stroke or transient ischemic attack) to reduce the risk of stroke and systemic embolism.

Usage and dosage:

Rivaroxaban Xarelto is taken orally. Rivaroxaban 10mg can be taken with food or alone. Rivaroxaban 15 mg or 20 mg tablets should be taken with food. For the prevention of venous thrombosis in adult patients undergoing elective hip or knee replacement surgery: The recommended dose is rivaroxaban 10 mg orally once daily. If the wound has stopped bleeding, the first dose of medication should be between 6 and 10 hours after surgery. For patients undergoing major hip surgery, the recommended course of treatment is 35 days. For patients undergoing major knee surgery, the recommended course of treatment is 12 days. If a missed dose occurs, the patient should take rivaroxaban immediately and continue taking the dose once daily the next day. Rivaroxaban Xarelto treats DVT (venous thrombosis) and reduces the risk of acute DVT recurrence and PE: The recommended dose for the initial treatment of acute DVT is 15 mg twice a day for the first three weeks, and then the dose for maintenance treatment and to reduce the risk of DVT recurrence and PE is 20 mg once a day.

Rivaroxaban Xarelto is used in adult patients with non-valvular atrial fibrillation to reduce the risk of stroke and systemic embolism: the recommended dose is 20 mg once a day, which is also the maximum recommended dose. For patients with low weight and advanced age (>75 years old), doctors can use 15 mg once a day as appropriate based on the patient's condition.

Adverse reactions:

The most common adverse reaction of taking Rivaroxaban Xarelto is bleeding, which manifests as nosebleeds, gum bleeding, gastrointestinal bleeding (blood vomiting, bloody stools), hematuria, intracranial hemorrhage, etc. Other adverse reactions include nausea, abdominal pain, elevated liver enzymes, cholestasis, sinusitis, limb pain, urinary tract infection, etc.

Things to note:

1. Bleeding risk: As detailed below, some subgroups of patients are at higher risk of bleeding. After initiation of treatment, these patients should be monitored closely for signs of bleeding complications. This can be accomplished by regular physical examination of the patient, close observation of surgical wound drainage, and regular determination of hemoglobin. Any unexplained decrease in hemoglobin or blood pressure should prompt a search for the site of bleeding.

2. Renal damage: In patients with severe renal impairment (creatinine clearance <30 mL/min), the plasma concentration of rivaroxaban Xarelto may be significantly increased, leading to an increased risk of bleeding. Rivaroxaban is not recommended for patients with creatinine clearance <15 mL/min. Rivaroxaban should be used with caution in patients with creatinine clearance 15-29 mL/min. Rivaroxaban should be used with caution in patients with moderate renal impairment (creatinine clearance 30-49 mL/min) when used concomitantly with other drugs that may increase rivaroxaban plasma concentrations.

The above is the content of the Xarelto instruction manual, I hope it can help you!

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