利伐沙班拜瑞妥作用与功效

In June 2009, it was officially launched in China under the trade name Xarelto and is used to prevent or reduce the formation of blood clots, deep vein thrombosis (DVT) and pulmonary embolism (PE) after hip or knee replacement surgery. Rivaroxaban is an anticoagulant drug and a new type of oral anticoagulant that inhibits coagulation factor X. Today we will learn more about the effects and efficacy of Rivaroxaban Xarelto.

Recently, a study published in the Journal of Thrombosis showed that monotherapy with the new oral anticoagulant rivaroxaban Xarelto in Chinese patients can effectively treat deep vein thrombosis and pulmonary embolism and prevent their subsequent recurrence. The study randomly assigned Chinese patients to two groups: oral rivaroxaban (15 mg twice daily for 3 weeks, followed by 20 mg once daily) or standard therapy (injectable enoxaparin bridged with a dose-adjusted vitamin K antagonist) for 3, 6, or 12 months.

The results showed that the two treatments were equally effective in treating acute symptomatic deep vein thrombosis and/or symptomatic pulmonary embolism, and the rivaroxaban group had a lower rate of major bleeding. In addition, the study also found that rivaroxaban Xarelto has similar efficacy in high-risk groups, such as elderly or frail patients, patients with kidney damage, cancer patients, and patients with larger clots in the body. Furthermore, rivaroxaban was well tolerated by Chinese patients and did not require routine coagulation monitoring, dose adjustments, or dietary restrictions.

The effect of Rivaroxaban Xarelto on prothrombin time (PT) has a dose-effect relationship. If NeopLastin is used for content measurement, it is closely related to the plasma concentration (correlation coefficient is 0.98). Different results may occur with other reagents. Reading the PT should be completed within seconds because the International Normalized Ratio (INR) is calibrated and validated only for coumarins and not for other anticoagulants. In patients undergoing major orthopedic surgery, 5/95th (percentile) PT was (NeopLastin) 13-25 seconds 2-4 hours after taking the tablet (when the effect is strongest) (baseline value before surgery was 12-15 seconds).

The above is the content of Xarelto effect, I hope it can help you!

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