利伐沙班漏服怎么处理？

How to deal with missed doses in patients with venous thrombosis?

1. Prevention of venous thrombosis in adult patients undergoing elective hip or knee replacement surgery

The recommended dose is rivaroxaban 10 mg orally once daily. If the wound has stopped bleeding, the first dose of medication should be between 6 and 10 hours after surgery.

Treatment of missed doses of rivaroxaban: If a missed dose occurs, the patient should take rivaroxaban immediately and continue taking the drug once daily the next day.

2. Treat DVT and reduce the risk of acute DVT recurrence and PE.

The recommended dose for initial treatment of acute DVT is 15 mg twice daily for the first three weeks, followed by 20 mg once daily for maintenance treatment and to reduce the risk of recurrent DVT and PE.

Management of missed doses of rivaroxaban: If a missed dose occurs during 15 mg twice daily treatment (days 1-21), the patient should take rivaroxaban immediately to ensure that 30 mg of rivaroxaban is taken daily. In this case, it may be necessary to take two 15 mg tablets at once. Thereafter, regular 15 mg twice daily dosing should be continued as recommended.

If a missed dose occurs during 20 mg once-daily treatment (day 22 and beyond), the patient should begin rivaroxaban immediately and continue to receive once-daily dosing at the recommended dose thereafter. The dose should not be doubled in one day to make up for a missed dose.

3. Used in adult patients with non-valvular atrial fibrillation to reduce the risk of stroke and systemic embolism

The recommended dose is 20 mg once a day, which is also the maximum recommended dose. For patients with low body weight and advanced age (>75 years old), doctors can use 15 mg once a day as appropriate based on the patient's condition.

Management of missed doses: If a missed dose occurs, the patient should take rivaroxaban immediately and continue receiving the once-daily dose the next day. The dose should not be doubled in one day to make up for a missed dose.

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