利伐沙班目前已知获批适应症有哪些？

(Alias: Xarelto) can selectively block the active site of factor xa. For example, antithrombin III activates factor xa through endogenous and exogenous pathways.

Rivaroxaban's dose-dependent inhibition in humans is an activity of factor xa. It uses some reagents to detect prothrombin time, activated partial prothrombin time and quantitative monitoring of heparin, which can detect dose-dependent prolongation. What are the currently approved indications for rivaroxaban?

Indications for Rivaroxaban:

1. For adult patients undergoing elective hip or knee replacement surgery to prevent venous thrombosis (VTE).

2. Used to treat venous thrombosis (DVT) in adults and reduce the risk of DVT recurrence and pulmonary embolism (PE) after acute DVT.

3. For use in adult patients with non-valvular atrial fibrillation who have one or more risk factors (such as congestive heart failure, hypertension, age ≥75 years, diabetes, history of stroke or transient ischemic attack) to reduce the risk of stroke and systemic embolism.

Regarding the side effects of taking rivaroxaban:

Rivaroxaban is a new oral anticoagulant that is currently widely used in clinical applications because it has its advantages. Compared with warfarin, it has a longer treatment time window, high bioavailability, and very few side effects. But it is an anticoagulant after all and has certain side effects.

Rivaroxaban can pass through the placenta. For pregnant women, whether it is used to prevent thrombosis or treat thrombosis, it will cause fetal malformation through the placenta. Both pregnant women and fetuses will be anticoagulated, causing fetal bleeding. Therefore, women should not take it if they are pregnant.

Food does not have a great impact on (Also known as: Xarelto). The drug has a certain degree of bioavailability, so if it is taken in large doses, the possibility of bleeding is relatively small, so there is no need to worry about this, because there is no need to monitor coagulation when taking the drug.