Xarelto（拜瑞妥）售价多少？

Rivaroxaban (Xarelto, Xarelto) is a small molecule oral anticoagulant jointly developed by Bayer and Johnson & Johnson. The indications of rivaroxaban (Xarelto, Xarelto) include: 1. Used in adult patients undergoing elective hip or knee replacement surgery to prevent venous thrombosis (VTE). 2. Used to treat venous thrombosis (DVT) in adults and reduce the risk of DVT recurrence and pulmonary embolism (PE) after acute DVT. 3. For use in adult patients with nonvalvular atrial fibrillation who have one or more risk factors (e.g., congestive heart failure, hypertension, age ≥75 years, diabetes, history of stroke or transient ischemic attack) to reduce the risk of stroke and systemic embolism. 

Rivaroxaban (Xarelto) highly selectively and competitively inhibits free and bound factor Xa and prothrombin activity, prolonging the activated partial thromboplastin time plate (APTT) and prothrombin time (PT) in a dose-dependent manner. The essential difference between rivaroxaban (Xarelto) and fondaparinux sodium/heparin is that it does not require the participation of antithrombin III and can directly antagonize free and bound factor Xa. Heparin requires antithrombin III to work and is ineffective against factor Xa in the prothrombin complex. 

Rivaroxaban (Xarelto) has been approved for marketing in many countries, and the price in different countries will vary. The selling price of Rivaroxaban (Xarelto, Xarelto) in the United States: Specification: 10mg-10 tablets/box, pharmacy price: US$156.24; Specification: 15mg-30 tablets/box, pharmacy price: US$438.67; Specification: 20mg-30 tablets/box, pharmacy price: US$553.65. The price of rivaroxaban (Xarelto, Xarelto) in China: Domestic rivaroxaban (Xarelto, Xarelto) is an original drug produced by Bayer Pharma AG/Germany Bayer Pharmaceuticals. Specification: 10mg-5 tablets/box, priced at about 138$; Specification: 15mg-7 tablets/box, priced at about 199$; Specification: 20mg-7 tablets/box, priced at about 263$. The specifications of rivaroxaban (Xarelto, Xarelto) listed abroad are 15mg*28 tablets; the price of 20mg*28 tablets is around $600. Please consult Medical Companion Travel for price details.