静脉血栓治疗用药-Xarelto

Rivaroxaban (Xarelto) is a highly selective, oral drug that directly inhibits factor Xa. By inhibiting factor Rivaroxaban (Xarelto) does not inhibit thrombin (activated factor II) and has not been shown to have an effect on platelets. Rivaroxaban (Xarelto) is approved for: 1. For the prevention of venous thrombosis (VTE) in adult patients undergoing elective hip or knee replacement surgery. 2. Used to treat venous thrombosis (DVT) in adults and reduce the risk of DVT recurrence and pulmonary embolism (PE) after acute DVT. 3. For use in adult patients with nonvalvular atrial fibrillation who have one or more risk factors (e.g., congestive heart failure, hypertension, age ≥75 years, diabetes, history of stroke or transient ischemic attack) to reduce the risk of stroke and systemic embolism.  

Rivaroxaban (Xarelto) is administered orally. Rivaroxaban (Xarelto) 10 mg can be taken with food or alone. Rivaroxaban (Xarelto) 15 mg or 20 mg tablets should be taken with food. For patients who cannot swallow the whole tablet, crush the 10 mg, 15 mg or 20 mg rivaroxaban (Xarelto) tablet before taking the medicine, mix it with applesauce and take it immediately. You should eat immediately after giving crushed rivaroxaban (Xarelto) 15 mg or 20 mg tablets. Or administration through nasogastric tube (NG) or gastric feeding tube: After determining the position of the gastric tube in the stomach, 10 mg, 15 mg or 20 mg rivaroxaban (Xarelto, Xarelto) tablets can also be crushed, mixed with 50 mL of water to form a suspension, and administered through a nasogastric tube or gastric feeding tube. Because the absorption of rivaroxaban (Xarelto, Xarelto) depends on the site of drug release, administration in the distal stomach should be avoided because administration in the distal stomach may decrease drug absorption, thereby reducing drug exposure. Food should be given by enteral nutrition immediately after administration of crushed rivaroxaban (Xarelto) 15 mg or 20 mg tablets. Crushed 10 mg, 15 mg, or 20 mg rivaroxaban (Xarelto) tablets are stable in water or applesauce for up to 4 hours. In vitro compatibility studies showed that rivaroxaban (Xarelto) did not adsorb from the suspension to PVC or silicone nasogastric tubes.