利伐沙班用法以及用量

Rivaroxaban is used primarily to prevent venous thrombosis in adult patients undergoing elective hip or knee replacement surgery. It can also be used in adult patients with non-valvular atrial fibrillation who have one or more risk factors to reduce the risk of stroke and systemic embolism.

So, what is the usage and dosage of rivaroxaban?

How to use and dose rivaroxaban:

Prevention of venous thrombosis in adults undergoing elective hip or knee replacement surgery

The recommended dose is rivaroxaban 10 mg orally once daily. If the wound has stopped bleeding, the first dose of medication should be between 6 and 10 hours after surgery.

For patients undergoing major hip surgery, the recommended course of treatment is 35 days.

For patients undergoing major knee surgery, the recommended course of treatment is 12 days.

If a missed dose occurs, the patient should take rivaroxaban immediately and continue taking the dose once daily the next day.

Treat DVT and reduce the risk of acute DVT recurrence and PE

The recommended dose for initial treatment of acute DVT is 15 mg twice daily for the first three weeks, followed by 20 mg once daily for maintenance treatment and to reduce the risk of recurrent DVT and PE.

The duration of treatment should be determined on an individual basis after careful evaluation of treatment benefit versus bleeding risk. Short-term treatment (3 months) should be based on transient risk factors (eg, recent surgery, trauma, immobilization), and long-term treatment should be based on permanent risk factors or idiopathic DVT. There is insufficient experience with the use of rivaroxaban for more than 12 months for this indication.

If a missed dose occurs during 15 mg twice daily treatment (Days 1-21), patients should take rivaroxaban immediately to ensure 30 mg of rivaroxaban is taken daily. In this case, it may be necessary to take two 15 mg tablets at once. Thereafter, regular 15 mg twice daily dosing should be continued as recommended.

If a missed dose occurs during 20 mg once-daily treatment (day 22 and beyond), the patient should begin rivaroxaban immediately and continue to receive once-daily dosing at the recommended dose thereafter. The dose should not be doubled in one day to make up for a missed dose.